FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047731321> ?p ?o ?g. }

• W3047731321 endingPage "111056" @default.
• W3047731321 startingPage "111056" @default.
• W3047731321 abstract "Abstract Alzheimer's is a progressive disorder of the nervous system. Prior studies suggested that physical activity contributes to the improvement of cognitive impairment and slows down pathogenesis of AD; however, the exact mechanisms for this have not been fully understood. Therefore, in this study, we examined the effect of aerobic training before and after induction of Alzheimer's on spatial learning and memory, expression of interleukin-1 beta (IL-1β), cAMP-responsive element-binding protein (pCREB), and Phosphodiesterase-5 (PDE-5) in the hippocampus of male rats Wistar. Aβ was microinjected into the CA1 area of the hippocampus animals. The moderate treadmill exercise protocols for pre and post induction of Alzheimer's were the same (5 days/week, for 4 weeks with a customized regime). The Morris Water Maze (MWM) method has been to assess spatial learning and memory. The real time-PCR method was used to measure gene expression. Our results showed that intra-hippocampal injection of Aβ1–42 impaired spatial learning and memory which was accompanied by reduced pCREB activity and elevated IL-1β and PDE-5 in the hippocampus of rats. In contrast, moderate treadmill exercise ameliorated the Aβ1–42-induced spatial learning and memory deficit, which was accompanied by restored pCREB activity and decreasing IL-1β and PDE-5 levels. In conclusion, our finding suggests that exercise before and after Alzheimer's induction leads to an increase in pCREB and an alleviation of inflammation which likely involved in ameliorating spatial learning and memory deficits in an animal model of AD." @default.
• W3047731321 created "2020-08-13" @default.
• W3047731321 creator A5029694671 @default.
• W3047731321 creator A5046942714 @default.
• W3047731321 creator A5074690948 @default.
• W3047731321 creator A5088866110 @default.
• W3047731321 creator A5090182497 @default.
• W3047731321 date "2020-10-01" @default.
• W3047731321 modified "2023-10-18" @default.
• W3047731321 title "Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression" @default.
• W3047731321 cites W1528717512 @default.
• W3047731321 cites W1861299606 @default.
• W3047731321 cites W1967258526 @default.
• W3047731321 cites W1972891705 @default.
• W3047731321 cites W1983102049 @default.
• W3047731321 cites W1985553766 @default.
• W3047731321 cites W1986925583 @default.
• W3047731321 cites W1989491769 @default.
• W3047731321 cites W1994394172 @default.
• W3047731321 cites W1995609628 @default.
• W3047731321 cites W1997322387 @default.
• W3047731321 cites W1997457117 @default.
• W3047731321 cites W1998411467 @default.
• W3047731321 cites W1999782689 @default.
• W3047731321 cites W2000265708 @default.
• W3047731321 cites W2005355670 @default.
• W3047731321 cites W2017899473 @default.
• W3047731321 cites W2018689082 @default.
• W3047731321 cites W2020895118 @default.
• W3047731321 cites W2024594664 @default.
• W3047731321 cites W2027048110 @default.
• W3047731321 cites W2030272885 @default.
• W3047731321 cites W2034986487 @default.
• W3047731321 cites W2035717344 @default.
• W3047731321 cites W2036396876 @default.
• W3047731321 cites W2038120217 @default.
• W3047731321 cites W2041183431 @default.
• W3047731321 cites W2041923645 @default.
• W3047731321 cites W2049268124 @default.
• W3047731321 cites W2051230113 @default.
• W3047731321 cites W2053298975 @default.
• W3047731321 cites W2054588589 @default.
• W3047731321 cites W2065596380 @default.
• W3047731321 cites W2070881916 @default.
• W3047731321 cites W2073040308 @default.
• W3047731321 cites W2078621811 @default.
• W3047731321 cites W2078779360 @default.
• W3047731321 cites W2080084480 @default.
• W3047731321 cites W2090661905 @default.
• W3047731321 cites W2092321567 @default.
• W3047731321 cites W2094570848 @default.
• W3047731321 cites W2104010831 @default.
• W3047731321 cites W2107277218 @default.
• W3047731321 cites W2108919575 @default.
• W3047731321 cites W2113005513 @default.
• W3047731321 cites W2116784956 @default.
• W3047731321 cites W2125186396 @default.
• W3047731321 cites W2127027544 @default.
• W3047731321 cites W2129030266 @default.
• W3047731321 cites W2143070083 @default.
• W3047731321 cites W2146864294 @default.
• W3047731321 cites W2151668600 @default.
• W3047731321 cites W2159483285 @default.
• W3047731321 cites W2169566060 @default.
• W3047731321 cites W2169916014 @default.
• W3047731321 cites W2170891630 @default.
• W3047731321 cites W2193466021 @default.
• W3047731321 cites W2214133783 @default.
• W3047731321 cites W2238119500 @default.
• W3047731321 cites W2243723775 @default.
• W3047731321 cites W2479234626 @default.
• W3047731321 cites W2555866292 @default.
• W3047731321 cites W2587087311 @default.
• W3047731321 cites W2783250611 @default.
• W3047731321 cites W2789381276 @default.
• W3047731321 cites W2808504196 @default.
• W3047731321 cites W2889422179 @default.
• W3047731321 cites W748543715 @default.
• W3047731321 doi "https://doi.org/10.1016/j.exger.2020.111056" @default.
• W3047731321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32791334" @default.
• W3047731321 hasPublicationYear "2020" @default.
• W3047731321 type Work @default.
• W3047731321 sameAs 3047731321 @default.
• W3047731321 citedByCount "11" @default.
• W3047731321 countsByYear W30477313212021 @default.
• W3047731321 countsByYear W30477313212022 @default.
• W3047731321 countsByYear W30477313212023 @default.
• W3047731321 crossrefType "journal-article" @default.
• W3047731321 hasAuthorship W3047731321A5029694671 @default.
• W3047731321 hasAuthorship W3047731321A5046942714 @default.
• W3047731321 hasAuthorship W3047731321A5074690948 @default.
• W3047731321 hasAuthorship W3047731321A5088866110 @default.
• W3047731321 hasAuthorship W3047731321A5090182497 @default.
• W3047731321 hasBestOaLocation W30477313212 @default.
• W3047731321 hasConcept C126322002 @default.
• W3047731321 hasConcept C15744967 @default.
• W3047731321 hasConcept C169760540 @default.
• W3047731321 hasConcept C2781464450 @default.

• next