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- W3047778880 abstract "Frontal top-down cortical neurons projecting to sensory cortical regions are well-positioned to integrate long-range inputs with local circuitry in frontal cortex to implement top-down attentional control of sensory regions. How adolescence contributes to the maturation of top-down neurons and associated local/long-range input balance, and the establishment of attentional control is poorly understood. Here we combine projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood. Chemogenetic suppression of top-down neuron activity selectively during adolescence, but not later periods, produces long-lasting visual attentional behavior deficits, and results in excessive loss of local excitatory inputs in adulthood. Our study reveals an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior." @default.
- W3047778880 created "2020-08-13" @default.
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- W3047778880 date "2020-08-07" @default.
- W3047778880 modified "2023-10-16" @default.
- W3047778880 title "Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice" @default.
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- W3047778880 doi "https://doi.org/10.1038/s41467-020-17787-0" @default.
- W3047778880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7414856" @default.
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