Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047873744> ?p ?o ?g. }
- W3047873744 endingPage "478" @default.
- W3047873744 startingPage "466" @default.
- W3047873744 abstract "Although there are many therapeutic strategies such as surgery and chemotherapy, the prognosis of osteosarcoma (OS) is still far from being satisfactory. It is urgent to develop more effective, tolerable and safe drugs for the treatment of OS. In the present study, we investigated the anti-OS activity of Alantolactone (ALT), a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium, and probed the possible mechanism involved. We demonstrated that ALT significantly inhibited cell proliferation of various human OS cell lines while had relative lower cytotoxicity against normal cells. Then, we validated that ALT reduced migration, decreased invasion possibly through reversing epithelial mesenchymal transition (EMT) process and suppressing Matrix metalloproteinases (MMPs). Moreover, we confirmed that ALT promoted apoptosis and arrested cell cycle at G2/M phase of human OS cells in vitro. In addition, we confirmed that ALT restrained tumor growth and metastasis of OS 143 cells in a xenograft model in vivo. Mechanistically, ALT inhibited the activity of Wnt/β-catenin and p38, ERK1/2 and JNK Mitogen Activated Protein Kinases (MAPKs) signal pathway. Notably, the combination of ALT and Wnt/β-catenin inhibitor, as well as the combination of ALT and MAPKs inhibitors resulted in a synergistically effect on inhibiting the proliferation, migration and invasion of OS cells. Collectively, our results validate the ALT may inhibit proliferation, metastasis and promotes apoptosis of human OS cells possibly through suppressing Wnt/β-Catenin and MAPKs signaling pathways." @default.
- W3047873744 created "2020-08-13" @default.
- W3047873744 creator A5021355100 @default.
- W3047873744 creator A5026571332 @default.
- W3047873744 creator A5030496125 @default.
- W3047873744 creator A5039093157 @default.
- W3047873744 creator A5058194179 @default.
- W3047873744 creator A5060399150 @default.
- W3047873744 creator A5062532389 @default.
- W3047873744 creator A5065956038 @default.
- W3047873744 creator A5070961992 @default.
- W3047873744 creator A5075228460 @default.
- W3047873744 date "2022-03-01" @default.
- W3047873744 modified "2023-10-15" @default.
- W3047873744 title "Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways" @default.
- W3047873744 cites W1621930076 @default.
- W3047873744 cites W1707872293 @default.
- W3047873744 cites W1972865309 @default.
- W3047873744 cites W2019469219 @default.
- W3047873744 cites W2043288146 @default.
- W3047873744 cites W2055202616 @default.
- W3047873744 cites W2079389145 @default.
- W3047873744 cites W2116508133 @default.
- W3047873744 cites W2123187473 @default.
- W3047873744 cites W2131269173 @default.
- W3047873744 cites W2134295452 @default.
- W3047873744 cites W2150922140 @default.
- W3047873744 cites W2322406496 @default.
- W3047873744 cites W2337636620 @default.
- W3047873744 cites W2344572926 @default.
- W3047873744 cites W2346520135 @default.
- W3047873744 cites W2408954743 @default.
- W3047873744 cites W2500192509 @default.
- W3047873744 cites W2522803584 @default.
- W3047873744 cites W2523549276 @default.
- W3047873744 cites W2538724037 @default.
- W3047873744 cites W2554186605 @default.
- W3047873744 cites W2572077158 @default.
- W3047873744 cites W2588869529 @default.
- W3047873744 cites W2595340740 @default.
- W3047873744 cites W2604896137 @default.
- W3047873744 cites W2734770420 @default.
- W3047873744 cites W2750320695 @default.
- W3047873744 cites W2766612189 @default.
- W3047873744 cites W2774414544 @default.
- W3047873744 cites W2775185528 @default.
- W3047873744 cites W2795364806 @default.
- W3047873744 cites W2810392784 @default.
- W3047873744 cites W2894500172 @default.
- W3047873744 cites W2897912817 @default.
- W3047873744 cites W2900422075 @default.
- W3047873744 cites W2901068426 @default.
- W3047873744 cites W2903870145 @default.
- W3047873744 cites W2904081063 @default.
- W3047873744 cites W2906067435 @default.
- W3047873744 cites W2907723942 @default.
- W3047873744 cites W2923360396 @default.
- W3047873744 cites W2947948353 @default.
- W3047873744 cites W2951598380 @default.
- W3047873744 cites W2952955129 @default.
- W3047873744 cites W2959743240 @default.
- W3047873744 cites W2968576117 @default.
- W3047873744 cites W2972174640 @default.
- W3047873744 cites W2973644065 @default.
- W3047873744 cites W2977609650 @default.
- W3047873744 cites W2993190115 @default.
- W3047873744 cites W2995152357 @default.
- W3047873744 cites W2995940075 @default.
- W3047873744 cites W3004223483 @default.
- W3047873744 cites W3006330194 @default.
- W3047873744 cites W3029713306 @default.
- W3047873744 cites W4211062330 @default.
- W3047873744 cites W4234603135 @default.
- W3047873744 doi "https://doi.org/10.1016/j.gendis.2020.07.014" @default.
- W3047873744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35224161" @default.
- W3047873744 hasPublicationYear "2022" @default.
- W3047873744 type Work @default.
- W3047873744 sameAs 3047873744 @default.
- W3047873744 citedByCount "10" @default.
- W3047873744 countsByYear W30478737442021 @default.
- W3047873744 countsByYear W30478737442022 @default.
- W3047873744 countsByYear W30478737442023 @default.
- W3047873744 crossrefType "journal-article" @default.
- W3047873744 hasAuthorship W3047873744A5021355100 @default.
- W3047873744 hasAuthorship W3047873744A5026571332 @default.
- W3047873744 hasAuthorship W3047873744A5030496125 @default.
- W3047873744 hasAuthorship W3047873744A5039093157 @default.
- W3047873744 hasAuthorship W3047873744A5058194179 @default.
- W3047873744 hasAuthorship W3047873744A5060399150 @default.
- W3047873744 hasAuthorship W3047873744A5062532389 @default.
- W3047873744 hasAuthorship W3047873744A5065956038 @default.
- W3047873744 hasAuthorship W3047873744A5070961992 @default.
- W3047873744 hasAuthorship W3047873744A5075228460 @default.
- W3047873744 hasBestOaLocation W30478737441 @default.
- W3047873744 hasConcept C109523444 @default.
- W3047873744 hasConcept C121608353 @default.
- W3047873744 hasConcept C137620995 @default.
- W3047873744 hasConcept C184235292 @default.