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- W3047880070 abstract "Radiotherapy is a crucial approach for treating tumors. However, radiation-induced aseptic inflammation is a common complication. Radiation pneumonitis is the acute manifestation of radiation-induced lung disease, and interleukin 6 (IL-6) is a major proinflammatory cytokine involved in radiation-induced lung injury. Here we found that silencing Zinc finger and BTB domain-containing protein 7B (Zbtb7b) resulted in higher radiation-induced IL-6 production in THP1 cells and BEAS-2B lung bronchial epithelial cells. Mechanistically, Zbtb7b recruited RNA demethylase ALKBH5 to IL6 mRNA. Subsequentially, it demethylated N6-methyladenosine (m6A) modification of IL6 mRNA and inhibited its nuclear export. Thus, Zbtb2b epigenetically suppresses irradiation-induced IL-6 production in the lungs via inhibiting the m6A modification and nucleocytoplasmic transport of IL6 mRNA, serving as a new potential predictive marker and therapeutic target in radiation pneumonitis treatment." @default.
- W3047880070 created "2020-08-13" @default.
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- W3047880070 date "2020-09-01" @default.
- W3047880070 modified "2023-10-14" @default.
- W3047880070 title "Zbtb7b suppresses aseptic inflammation by regulating m6A modification of IL6 mRNA" @default.
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- W3047880070 doi "https://doi.org/10.1016/j.bbrc.2020.07.011" @default.
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