FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047888905> ?p ?o ?g. }

• W3047888905 abstract "Abstract Background Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies. To ensure that new therapies evaluated in animal models are translatable to humans, studies must evaluate clinically relevant and patient-important outcomes, including neurological symptoms and sequelae. Methods We developed and tested a functional observational battery to quantify the severity of a variety of relevant neurological and clinical symptoms in a rat model of bacterial meningitis. The functional observational battery included symptoms relating to general clinical signs, gait and posture abnormalities, involuntary motor movements, focal neurological signs, and neuromotor abnormalities which were scored according to severity and summed to obtain a combined clinical and neurological score. To test the functional observational battery, adult Sprague-Dawley rats were infected by intracisternal injection of a clinical isolate of Streptococcus pneumoniae . Rats were evaluated for 6 days following the infection. Results Pneumococcal meningitis was not lethal in this model; however, it induced severe neurological symptoms. Most common symptoms were hearing loss (75% of infected vs 0% of control rats; p = 0.0003), involuntary motor movements (75% of infected vs 0% of control rats; p = 0.0003), and gait and posture abnormality (67% of infected vs 0% of control rats; p = 0.0013). Infected rats had a higher combined score when determined by the functional observational battery than control rats at all time points (24 h 12.7 ± 4.0 vs 4.0 ± 2.0; 48 h 17.3 ± 7.1 vs 3.4 ± 1.8; 6 days 17.8 ± 7.4 vs 1.7 ± 2.4; p < 0.0001 for all). Conclusions The functional observational battery described here detects clinically relevant neurological sequelae of bacterial meningitis and could be a useful tool when testing new therapeutics in rat models of meningitis." @default.
• W3047888905 created "2020-08-13" @default.
• W3047888905 creator A5003949713 @default.
• W3047888905 creator A5007371335 @default.
• W3047888905 creator A5019078326 @default.
• W3047888905 creator A5042628195 @default.
• W3047888905 creator A5061549353 @default.
• W3047888905 creator A5077117137 @default.
• W3047888905 creator A5081024969 @default.
• W3047888905 date "2020-08-08" @default.
• W3047888905 modified "2023-10-16" @default.
• W3047888905 title "A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis" @default.
• W3047888905 cites W1481603087 @default.
• W3047888905 cites W1493580531 @default.
• W3047888905 cites W1966976587 @default.
• W3047888905 cites W1969213054 @default.
• W3047888905 cites W1987054870 @default.
• W3047888905 cites W1990080997 @default.
• W3047888905 cites W2008757142 @default.
• W3047888905 cites W2014923210 @default.
• W3047888905 cites W2017031876 @default.
• W3047888905 cites W2030260413 @default.
• W3047888905 cites W2036386442 @default.
• W3047888905 cites W2036763047 @default.
• W3047888905 cites W2043632422 @default.
• W3047888905 cites W2045330187 @default.
• W3047888905 cites W2055918489 @default.
• W3047888905 cites W2059845269 @default.
• W3047888905 cites W2076024310 @default.
• W3047888905 cites W2090232968 @default.
• W3047888905 cites W2097764701 @default.
• W3047888905 cites W2103946141 @default.
• W3047888905 cites W2120455620 @default.
• W3047888905 cites W2121998559 @default.
• W3047888905 cites W2123395436 @default.
• W3047888905 cites W2131433169 @default.
• W3047888905 cites W2145453264 @default.
• W3047888905 cites W2159648246 @default.
• W3047888905 cites W2167395319 @default.
• W3047888905 cites W2184687076 @default.
• W3047888905 cites W2205988876 @default.
• W3047888905 cites W2326122211 @default.
• W3047888905 cites W2341791533 @default.
• W3047888905 cites W2468382043 @default.
• W3047888905 cites W2477984173 @default.
• W3047888905 cites W2513082141 @default.
• W3047888905 cites W2547971545 @default.
• W3047888905 cites W2577370916 @default.
• W3047888905 cites W2611216891 @default.
• W3047888905 cites W2765814484 @default.
• W3047888905 cites W2772414831 @default.
• W3047888905 cites W2795555810 @default.
• W3047888905 cites W2807800060 @default.
• W3047888905 cites W2887043501 @default.
• W3047888905 cites W2887409253 @default.
• W3047888905 cites W2888649524 @default.
• W3047888905 cites W2896525402 @default.
• W3047888905 cites W2939444901 @default.
• W3047888905 cites W2947352629 @default.
• W3047888905 cites W2951035033 @default.
• W3047888905 cites W4294214983 @default.
• W3047888905 doi "https://doi.org/10.1186/s40635-020-00331-1" @default.
• W3047888905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7415049" @default.
• W3047888905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32770475" @default.
• W3047888905 hasPublicationYear "2020" @default.
• W3047888905 type Work @default.
• W3047888905 sameAs 3047888905 @default.
• W3047888905 citedByCount "3" @default.
• W3047888905 countsByYear W30478889052021 @default.
• W3047888905 countsByYear W30478889052022 @default.
• W3047888905 countsByYear W30478889052023 @default.
• W3047888905 crossrefType "journal-article" @default.
• W3047888905 hasAuthorship W3047888905A5003949713 @default.
• W3047888905 hasAuthorship W3047888905A5007371335 @default.
• W3047888905 hasAuthorship W3047888905A5019078326 @default.
• W3047888905 hasAuthorship W3047888905A5042628195 @default.
• W3047888905 hasAuthorship W3047888905A5061549353 @default.
• W3047888905 hasAuthorship W3047888905A5077117137 @default.
• W3047888905 hasAuthorship W3047888905A5081024969 @default.
• W3047888905 hasBestOaLocation W30478889051 @default.
• W3047888905 hasConcept C120665830 @default.
• W3047888905 hasConcept C121332964 @default.
• W3047888905 hasConcept C126322002 @default.
• W3047888905 hasConcept C141071460 @default.
• W3047888905 hasConcept C187212893 @default.
• W3047888905 hasConcept C23131810 @default.
• W3047888905 hasConcept C2780168130 @default.
• W3047888905 hasConcept C2781026528 @default.
• W3047888905 hasConcept C2781253189 @default.
• W3047888905 hasConcept C501593827 @default.
• W3047888905 hasConcept C61511704 @default.
• W3047888905 hasConcept C71924100 @default.
• W3047888905 hasConcept C86803240 @default.
• W3047888905 hasConcept C89423630 @default.
• W3047888905 hasConceptScore W3047888905C120665830 @default.
• W3047888905 hasConceptScore W3047888905C121332964 @default.
• W3047888905 hasConceptScore W3047888905C126322002 @default.
• W3047888905 hasConceptScore W3047888905C141071460 @default.
• W3047888905 hasConceptScore W3047888905C187212893 @default.
• W3047888905 hasConceptScore W3047888905C23131810 @default.

• next