Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047903500> ?p ?o ?g. }
- W3047903500 abstract "COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2 coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor for severity and mortality of COVID-19. Recent studies support that COVID-19 has effects beyond the respiratory tract, with vascular complications arising as relevant factors worsening its prognosis, then making patients with previous vascular disease more prone to severity or fatal outcome. Angiotensin-II converting enzime-2 (ACE2) has been proposed as preferred receptor for SARS-CoV-2 host infection, yet specific proteins participating in the virus entry are not fully known. SARS-CoV-2 might use other co-receptor or auxiliary proteins allowing virus infection. In silico experiments proposed that SARS-CoV-2 might bind dipeptiyl peptidase 4 (DPP4/CD26), which was stablished previously as receptor for MERS-CoV. The renin-angiotensin-aldosterone system (RAAS) component ACE2 and DPP4 are proteins upregulated in diabetes. Imbalance of the RAAS and direct effect of soluble DPP4 exert deleterious vascular effects. We hypothesize that diabetic patients might be more affected by COVID-19 due to increased presence ACE2 and DPP4 mediating infection and contributing to a compromised vasculature. Here, we discuss the role of ACE2 and DPP4 as relevant factors linking the risk of SARS-CoV-2 infection and severity of COVID-19 in diabetic patients and present an outlook on therapeutic potential of current drugs targeted against RAAS and DPP4 to treat or prevent COVID-19-derived vascular complications. Diabetes affects more than 400 million people worldwide, thus better understanding of how they are affected by COVID-19 holds an important benefit to fight against this disease with pandemic proportions." @default.
- W3047903500 created "2020-08-13" @default.
- W3047903500 creator A5018887396 @default.
- W3047903500 creator A5031987417 @default.
- W3047903500 creator A5033408967 @default.
- W3047903500 creator A5036159024 @default.
- W3047903500 creator A5051448235 @default.
- W3047903500 creator A5061334930 @default.
- W3047903500 date "2020-08-07" @default.
- W3047903500 modified "2023-10-18" @default.
- W3047903500 title "DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications?" @default.
- W3047903500 cites W1507910610 @default.
- W3047903500 cites W1570779967 @default.
- W3047903500 cites W1966238900 @default.
- W3047903500 cites W1988174091 @default.
- W3047903500 cites W1989425827 @default.
- W3047903500 cites W1991173174 @default.
- W3047903500 cites W2001535323 @default.
- W3047903500 cites W2005951646 @default.
- W3047903500 cites W2006473328 @default.
- W3047903500 cites W2014448033 @default.
- W3047903500 cites W2015988613 @default.
- W3047903500 cites W2016632734 @default.
- W3047903500 cites W2019361592 @default.
- W3047903500 cites W2023670145 @default.
- W3047903500 cites W2025233502 @default.
- W3047903500 cites W2031438601 @default.
- W3047903500 cites W2033260105 @default.
- W3047903500 cites W2045923887 @default.
- W3047903500 cites W2047730645 @default.
- W3047903500 cites W2051738649 @default.
- W3047903500 cites W2060629558 @default.
- W3047903500 cites W2062779832 @default.
- W3047903500 cites W2062817591 @default.
- W3047903500 cites W2065729749 @default.
- W3047903500 cites W2066073474 @default.
- W3047903500 cites W2072190599 @default.
- W3047903500 cites W2080468281 @default.
- W3047903500 cites W2086440246 @default.
- W3047903500 cites W2086731797 @default.
- W3047903500 cites W2087638953 @default.
- W3047903500 cites W2091638124 @default.
- W3047903500 cites W2091671824 @default.
- W3047903500 cites W2094758439 @default.
- W3047903500 cites W2096057710 @default.
- W3047903500 cites W2097995302 @default.
- W3047903500 cites W2099475256 @default.
- W3047903500 cites W2102232978 @default.
- W3047903500 cites W2104079863 @default.
- W3047903500 cites W2108806929 @default.
- W3047903500 cites W2109288527 @default.
- W3047903500 cites W2109688740 @default.
- W3047903500 cites W2114531479 @default.
- W3047903500 cites W2114792859 @default.
- W3047903500 cites W2116898765 @default.
- W3047903500 cites W2118638261 @default.
- W3047903500 cites W2119111857 @default.
- W3047903500 cites W2123629330 @default.
- W3047903500 cites W2123906295 @default.
- W3047903500 cites W2125316296 @default.
- W3047903500 cites W2138043907 @default.
- W3047903500 cites W2154803239 @default.
- W3047903500 cites W2158498099 @default.
- W3047903500 cites W2162127423 @default.
- W3047903500 cites W2163610648 @default.
- W3047903500 cites W2165719301 @default.
- W3047903500 cites W2276899615 @default.
- W3047903500 cites W2320858969 @default.
- W3047903500 cites W2407030308 @default.
- W3047903500 cites W2486241607 @default.
- W3047903500 cites W2565541830 @default.
- W3047903500 cites W2579499065 @default.
- W3047903500 cites W2582514900 @default.
- W3047903500 cites W2588199171 @default.
- W3047903500 cites W2600318499 @default.
- W3047903500 cites W2603614172 @default.
- W3047903500 cites W2607875207 @default.
- W3047903500 cites W2743822989 @default.
- W3047903500 cites W2752614382 @default.
- W3047903500 cites W2753465515 @default.
- W3047903500 cites W2780715796 @default.
- W3047903500 cites W2800654584 @default.
- W3047903500 cites W2800730777 @default.
- W3047903500 cites W2888625680 @default.
- W3047903500 cites W2894726433 @default.
- W3047903500 cites W2898394729 @default.
- W3047903500 cites W2915311716 @default.
- W3047903500 cites W2927176460 @default.
- W3047903500 cites W2940177310 @default.
- W3047903500 cites W2941373284 @default.
- W3047903500 cites W2942158757 @default.
- W3047903500 cites W2956072935 @default.
- W3047903500 cites W2963788244 @default.
- W3047903500 cites W2966692841 @default.
- W3047903500 cites W2971955644 @default.
- W3047903500 cites W2974984390 @default.
- W3047903500 cites W2981809682 @default.
- W3047903500 cites W2997705713 @default.
- W3047903500 cites W3001118548 @default.
- W3047903500 cites W3004318991 @default.