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• W3047952203 abstract "<h2>Abstract</h2><h3>Background</h3> It has been shown that dihydroartemisinin (DHA) is effective in the treatment of malaria. Recently studies have demonstrated that DHA also regulates tumor cell growth, angiogenesis, T cell differentiation and generation. However, how DHA affects melanoma development remains poorly defined. <h3>Objectives</h3> To investigate the effects of DHA on the proliferation and migration of melanoma <i>in vivo</i> and <i>in vitro</i>, and to explore its possible mechanism. <h3>Methods</h3> B16F10 cells and melanoma-bearing BALB/c mice were used to investigate the effects of DHA on melanoma. <h3>Results</h3> DHA had inhibitory effect on melanoma proliferation in a time-and dose-dependent manner. Treatment of DHA attenuated melanoma severity and histopathological changes in BALB/c mice. DHA also inhibited melanoma invasion, migration, and community formation in a dose-dependent manner. Flow cytometry revealed a significant increase in IFN-γ⁺CD8⁺ T cells in the DHA groups. In tumor microenvironment and spleen, DHA induced expansion of CD8⁺CTL, while, CD4⁺CD25⁺Foxp3⁺ regulatory T (Treg) cells and IL-10⁺CD4⁺CD25⁺ T cells were normalized by DHA treatment. DHA diminished expression of IL-10 and IL-6, and increased the expression of IFN-γ in the tumor and spleen. Moreover, DHA administration significantly promoted the mitochondrial apoptosis of melanoma by regulating the STAT3 pathway. <h3>Conclusion</h3> DHA induces mitochondrial apoptosis and alters cytokines expression by inhibiting the phosphorylation of STAT3. DHA improves anti-tumor immunity in mice through controlling CD8⁺CTL function by counteracting IL-10-dependent Treg cells suppression, which promises to be an alternative drug for melanoma." @default.
• W3047952203 created "2020-08-13" @default.
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• W3047952203 date "2020-09-01" @default.
• W3047952203 modified "2023-10-15" @default.
• W3047952203 title "Dihydroartemisinin inhibits melanoma by regulating CTL/Treg anti-tumor immunity and STAT3-mediated apoptosis via IL-10 dependent manner" @default.
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• W3047952203 doi "https://doi.org/10.1016/j.jdermsci.2020.08.001" @default.
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