FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047961546> ?p ?o ?g. }

• W3047961546 endingPage "15" @default.
• W3047961546 startingPage "15" @default.
• W3047961546 abstract "Coronavirus Disease 2019 (COVID-19) is a rapidly evolving global pandemic for which more than a thousand clinical trials have been registered to secure therapeutic effectiveness, expeditiously. Most of these are single-center non-randomized studies rather than multi-center, randomized controlled trials. Single-arm trials have several limitations and may be conducted when spontaneous improvement is not anticipated, small placebo effect exists, and randomization to a placebo is not ethical. In an emergency where saving lives takes precedence, it is ethical to conduct trials with any scientifically proven design, however, safety must not be compromised. A phase II or III trial can be conducted directly in a pandemic with appropriate checkpoints and stopping rules. COVID-19 has two management paradigms- antivirals, or treatment of its complications. Simultaneous assessment of two different treatments can be done using 2 × 2 factorial schema. World Health Organization's SOLIDARITY trial is a classic example of the global research protocol which can evaluate the preferred treatment to combat COVID-19 pandemic. Short of that, a trial design must incorporate the practicality of the intervention used, and an appropriate primary endpoint which should ideally be a clinical outcome. Collaboration between institutions is needed more than ever to successfully execute and accrue in randomized trials." @default.
• W3047961546 created "2020-08-13" @default.
• W3047961546 creator A5023108730 @default.
• W3047961546 creator A5043033429 @default.
• W3047961546 creator A5070148764 @default.
• W3047961546 date "2020-01-01" @default.
• W3047961546 modified "2023-10-13" @default.
• W3047961546 title "Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design" @default.
• W3047961546 cites W2006918106 @default.
• W3047961546 cites W2030894970 @default.
• W3047961546 cites W2108100959 @default.
• W3047961546 cites W2238187692 @default.
• W3047961546 cites W2544612685 @default.
• W3047961546 cites W2564361602 @default.
• W3047961546 cites W2764308423 @default.
• W3047961546 cites W3010930696 @default.
• W3047961546 cites W3010992334 @default.
• W3047961546 cites W3012379316 @default.
• W3047961546 cites W3013899502 @default.
• W3047961546 cites W3014333693 @default.
• W3047961546 cites W3014386829 @default.
• W3047961546 cites W3015490759 @default.
• W3047961546 cites W3015620943 @default.
• W3047961546 cites W3017796721 @default.
• W3047961546 cites W3018023298 @default.
• W3047961546 cites W3022970339 @default.
• W3047961546 doi "https://doi.org/10.2991/jegh.k.200729.001" @default.
• W3047961546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7958277" @default.
• W3047961546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33009729" @default.
• W3047961546 hasPublicationYear "2020" @default.
• W3047961546 type Work @default.
• W3047961546 sameAs 3047961546 @default.
• W3047961546 citedByCount "2" @default.
• W3047961546 countsByYear W30479615462021 @default.
• W3047961546 crossrefType "journal-article" @default.
• W3047961546 hasAuthorship W3047961546A5023108730 @default.
• W3047961546 hasAuthorship W3047961546A5043033429 @default.
• W3047961546 hasAuthorship W3047961546A5070148764 @default.
• W3047961546 hasBestOaLocation W30479615461 @default.
• W3047961546 hasConcept C107062074 @default.
• W3047961546 hasConcept C116675565 @default.
• W3047961546 hasConcept C126322002 @default.
• W3047961546 hasConcept C12713177 @default.
• W3047961546 hasConcept C154945302 @default.
• W3047961546 hasConcept C15744967 @default.
• W3047961546 hasConcept C159047783 @default.
• W3047961546 hasConcept C17744445 @default.
• W3047961546 hasConcept C199539241 @default.
• W3047961546 hasConcept C2778137277 @default.
• W3047961546 hasConcept C2778767146 @default.
• W3047961546 hasConcept C2779134260 @default.
• W3047961546 hasConcept C2779728303 @default.
• W3047961546 hasConcept C3006700255 @default.
• W3047961546 hasConcept C3007834351 @default.
• W3047961546 hasConcept C3008058167 @default.
• W3047961546 hasConcept C41008148 @default.
• W3047961546 hasConcept C512399662 @default.
• W3047961546 hasConcept C524204448 @default.
• W3047961546 hasConcept C535046627 @default.
• W3047961546 hasConcept C71924100 @default.
• W3047961546 hasConcept C77805123 @default.
• W3047961546 hasConcept C89623803 @default.
• W3047961546 hasConceptScore W3047961546C107062074 @default.
• W3047961546 hasConceptScore W3047961546C116675565 @default.
• W3047961546 hasConceptScore W3047961546C126322002 @default.
• W3047961546 hasConceptScore W3047961546C12713177 @default.
• W3047961546 hasConceptScore W3047961546C154945302 @default.
• W3047961546 hasConceptScore W3047961546C15744967 @default.
• W3047961546 hasConceptScore W3047961546C159047783 @default.
• W3047961546 hasConceptScore W3047961546C17744445 @default.
• W3047961546 hasConceptScore W3047961546C199539241 @default.
• W3047961546 hasConceptScore W3047961546C2778137277 @default.
• W3047961546 hasConceptScore W3047961546C2778767146 @default.
• W3047961546 hasConceptScore W3047961546C2779134260 @default.
• W3047961546 hasConceptScore W3047961546C2779728303 @default.
• W3047961546 hasConceptScore W3047961546C3006700255 @default.
• W3047961546 hasConceptScore W3047961546C3007834351 @default.
• W3047961546 hasConceptScore W3047961546C3008058167 @default.
• W3047961546 hasConceptScore W3047961546C41008148 @default.
• W3047961546 hasConceptScore W3047961546C512399662 @default.
• W3047961546 hasConceptScore W3047961546C524204448 @default.
• W3047961546 hasConceptScore W3047961546C535046627 @default.
• W3047961546 hasConceptScore W3047961546C71924100 @default.
• W3047961546 hasConceptScore W3047961546C77805123 @default.
• W3047961546 hasConceptScore W3047961546C89623803 @default.
• W3047961546 hasIssue "1" @default.
• W3047961546 hasLocation W30479615461 @default.
• W3047961546 hasLocation W30479615462 @default.
• W3047961546 hasLocation W30479615463 @default.
• W3047961546 hasOpenAccess W3047961546 @default.
• W3047961546 hasPrimaryLocation W30479615461 @default.
• W3047961546 hasRelatedWork W3017171836 @default.
• W3047961546 hasRelatedWork W3036899716 @default.
• W3047961546 hasRelatedWork W3040137343 @default.
• W3047961546 hasRelatedWork W3042427510 @default.
• W3047961546 hasRelatedWork W3045573749 @default.
• W3047961546 hasRelatedWork W3127941442 @default.
• W3047961546 hasRelatedWork W3199363150 @default.

• next