FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047982008> ?p ?o ?g. }

• W3047982008 abstract "BACKGROUND:Colorectal cancer (CRC) is one of the most common malignancies worldwide. Overall survival (OS) of patients is largely dependent on disease stage at diagnosis and/or surgical resection. TCN1 mainly encodes the vitamin B12 transporter, transcobalamin. Early studies show that TCN1 is a marker of CRC progression, but the impact of TCN1 on survival is unclear. MATERIAL AND METHODS:We reviewed and analyzed colorectal tumor records, summarized the clinicopathological data, performed immunohistochemical detection of TCN1 again, and semi-quantitatively analyzed protein expression in tumor tissue, non-tumor tissue, and lymph nodes. We followed up patients for 5-year survival. RESULTS:Of 123 patients, 60 (48.7%) had a strong TCN1 immunohistochemical reaction, 36 (29.3%) had a moderate immune response, and 27 (22.0%) had weak expression. The level of immunohistochemical reactivity of TCN1 was correlated with the degree of histological differentiation (H (2.92)=4.976; P=0.083). Survival analysis showed that OS in patients with low TCN1 expression was significantly longer than that in the medium and high TCN1 expression groups (P=0.045). Five-year OS in patients with low, medium, and high TCN1 expression was 88.9%, 50.0%, and 40.0%, respectively. In univariate analysis, TCN1 immune expression was significantly correlated with the 5-year survival rate. CONCLUSIONS:Although independent risk factors affecting survival of patients with CRC are age, serum CA125, CA19-9, lymph node metastasis, and nerve invasion, negative factors affecting overall 5-year survival in TCN1 should not be ignored, because its high expression suggests a worse clinical prognosis." @default.
• W3047982008 created "2020-08-13" @default.
• W3047982008 creator A5019945393 @default.
• W3047982008 creator A5033532580 @default.
• W3047982008 creator A5040255727 @default.
• W3047982008 creator A5042358523 @default.
• W3047982008 creator A5076056939 @default.
• W3047982008 creator A5089787180 @default.
• W3047982008 creator A5089808670 @default.
• W3047982008 date "2020-07-23" @default.
• W3047982008 modified "2023-10-02" @default.
• W3047982008 title "Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors" @default.
• W3047982008 cites W1632443824 @default.
• W3047982008 cites W1966510676 @default.
• W3047982008 cites W1969051276 @default.
• W3047982008 cites W1984490534 @default.
• W3047982008 cites W2041674754 @default.
• W3047982008 cites W2052010170 @default.
• W3047982008 cites W2065074963 @default.
• W3047982008 cites W2071831014 @default.
• W3047982008 cites W2077180647 @default.
• W3047982008 cites W2086810487 @default.
• W3047982008 cites W2087178629 @default.
• W3047982008 cites W2119540244 @default.
• W3047982008 cites W2122273161 @default.
• W3047982008 cites W2132512789 @default.
• W3047982008 cites W2146970599 @default.
• W3047982008 cites W2150625137 @default.
• W3047982008 cites W2168155849 @default.
• W3047982008 cites W2408600484 @default.
• W3047982008 cites W2416620343 @default.
• W3047982008 cites W2418462368 @default.
• W3047982008 cites W2436711097 @default.
• W3047982008 cites W2467345490 @default.
• W3047982008 cites W2619504739 @default.
• W3047982008 cites W2742607629 @default.
• W3047982008 cites W2763160207 @default.
• W3047982008 cites W2782071114 @default.
• W3047982008 cites W2789840033 @default.
• W3047982008 cites W2808293799 @default.
• W3047982008 cites W2967205069 @default.
• W3047982008 cites W2343473475 @default.
• W3047982008 doi "https://doi.org/10.12659/msm.923828" @default.
• W3047982008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7397756" @default.
• W3047982008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32753569" @default.
• W3047982008 hasPublicationYear "2020" @default.
• W3047982008 type Work @default.
• W3047982008 sameAs 3047982008 @default.
• W3047982008 citedByCount "8" @default.
• W3047982008 countsByYear W30479820082021 @default.
• W3047982008 countsByYear W30479820082022 @default.
• W3047982008 countsByYear W30479820082023 @default.
• W3047982008 crossrefType "journal-article" @default.
• W3047982008 hasAuthorship W3047982008A5019945393 @default.
• W3047982008 hasAuthorship W3047982008A5033532580 @default.
• W3047982008 hasAuthorship W3047982008A5040255727 @default.
• W3047982008 hasAuthorship W3047982008A5042358523 @default.
• W3047982008 hasAuthorship W3047982008A5076056939 @default.
• W3047982008 hasAuthorship W3047982008A5089787180 @default.
• W3047982008 hasAuthorship W3047982008A5089808670 @default.
• W3047982008 hasBestOaLocation W30479820082 @default.
• W3047982008 hasConcept C10515644 @default.
• W3047982008 hasConcept C121608353 @default.
• W3047982008 hasConcept C126322002 @default.
• W3047982008 hasConcept C142724271 @default.
• W3047982008 hasConcept C143998085 @default.
• W3047982008 hasConcept C144301174 @default.
• W3047982008 hasConcept C146357865 @default.
• W3047982008 hasConcept C151730666 @default.
• W3047982008 hasConcept C204232928 @default.
• W3047982008 hasConcept C2780849966 @default.
• W3047982008 hasConcept C38180746 @default.
• W3047982008 hasConcept C526805850 @default.
• W3047982008 hasConcept C71924100 @default.
• W3047982008 hasConcept C86803240 @default.
• W3047982008 hasConcept C90924648 @default.
• W3047982008 hasConceptScore W3047982008C10515644 @default.
• W3047982008 hasConceptScore W3047982008C121608353 @default.
• W3047982008 hasConceptScore W3047982008C126322002 @default.
• W3047982008 hasConceptScore W3047982008C142724271 @default.
• W3047982008 hasConceptScore W3047982008C143998085 @default.
• W3047982008 hasConceptScore W3047982008C144301174 @default.
• W3047982008 hasConceptScore W3047982008C146357865 @default.
• W3047982008 hasConceptScore W3047982008C151730666 @default.
• W3047982008 hasConceptScore W3047982008C204232928 @default.
• W3047982008 hasConceptScore W3047982008C2780849966 @default.
• W3047982008 hasConceptScore W3047982008C38180746 @default.
• W3047982008 hasConceptScore W3047982008C526805850 @default.
• W3047982008 hasConceptScore W3047982008C71924100 @default.
• W3047982008 hasConceptScore W3047982008C86803240 @default.
• W3047982008 hasConceptScore W3047982008C90924648 @default.
• W3047982008 hasLocation W30479820081 @default.
• W3047982008 hasLocation W30479820082 @default.
• W3047982008 hasOpenAccess W3047982008 @default.
• W3047982008 hasPrimaryLocation W30479820081 @default.
• W3047982008 hasRelatedWork W1985349485 @default.
• W3047982008 hasRelatedWork W2013102863 @default.
• W3047982008 hasRelatedWork W2187444798 @default.
• W3047982008 hasRelatedWork W2361700749 @default.
• W3047982008 hasRelatedWork W2367054191 @default.

• next