FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047983903> ?p ?o ?g. }

• W3047983903 endingPage "139" @default.
• W3047983903 startingPage "133" @default.
• W3047983903 abstract "Insulin-like growth factor binding protein 3 (IGFBP3) is a multifunctional protein, able either to stimulate the cell growth or to promote apoptosis. In particular, IGFBP3 plays significant role in propagation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs) (Vassilieva et al., 2020). We undertook CRISPR/Cas9-mediated IGFBP3 knockout in an effort to decelerate stress-induced senescence in MESCs, but, unexpectedly, IGFBP3-knockout MESCs culture acquired chondrocyte-like features, such as cell condensation and aggregation. We revealed that IGFBP3-knockout MESCs completely lost CD73 and CD90 MESCs positive surface markers, and significantly decreased expression of CD105 and CD146 MESCs positive surface markers. In addition, we found IGFBP3-knockout MESCs aggregates positively stained for Alcian Blue. We also detected expression of collagen type II in IGFBP3-knockout MESCs. The obtained results indicate that MESCs lost stemness after IGFBP3-knockout and underwent differentiation toward chondrogenic lineage. Our findings can enlighten IGFBP3 role in regulation of MESCs chondrogenesis." @default.
• W3047983903 created "2020-08-13" @default.
• W3047983903 creator A5017069216 @default.
• W3047983903 creator A5041165007 @default.
• W3047983903 creator A5047413049 @default.
• W3047983903 creator A5052954776 @default.
• W3047983903 creator A5056870331 @default.
• W3047983903 creator A5057533296 @default.
• W3047983903 creator A5072115336 @default.
• W3047983903 creator A5077963098 @default.
• W3047983903 date "2020-10-01" @default.
• W3047983903 modified "2023-10-10" @default.
• W3047983903 title "Chondrogenic differentiation followed IGFBP3 loss in human endometrial mesenchymal stem cells" @default.
• W3047983903 cites W1916127119 @default.
• W3047983903 cites W1965245788 @default.
• W3047983903 cites W1966905303 @default.
• W3047983903 cites W1970373283 @default.
• W3047983903 cites W1975508950 @default.
• W3047983903 cites W1977632347 @default.
• W3047983903 cites W1983288748 @default.
• W3047983903 cites W1984143239 @default.
• W3047983903 cites W1990455352 @default.
• W3047983903 cites W1995365562 @default.
• W3047983903 cites W1995449145 @default.
• W3047983903 cites W1996331824 @default.
• W3047983903 cites W1996526080 @default.
• W3047983903 cites W2004639015 @default.
• W3047983903 cites W2008726208 @default.
• W3047983903 cites W2013639504 @default.
• W3047983903 cites W2016259832 @default.
• W3047983903 cites W2047166199 @default.
• W3047983903 cites W2056510698 @default.
• W3047983903 cites W2066358298 @default.
• W3047983903 cites W2078363576 @default.
• W3047983903 cites W2080238550 @default.
• W3047983903 cites W2087640406 @default.
• W3047983903 cites W2087640963 @default.
• W3047983903 cites W2131157113 @default.
• W3047983903 cites W2137900822 @default.
• W3047983903 cites W2140819020 @default.
• W3047983903 cites W2153949260 @default.
• W3047983903 cites W2164217401 @default.
• W3047983903 cites W2166765590 @default.
• W3047983903 cites W2207837055 @default.
• W3047983903 cites W2469481756 @default.
• W3047983903 cites W2900761534 @default.
• W3047983903 cites W2943914150 @default.
• W3047983903 cites W2965601029 @default.
• W3047983903 cites W2975889028 @default.
• W3047983903 doi "https://doi.org/10.1016/j.bbrc.2020.07.064" @default.
• W3047983903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782147" @default.
• W3047983903 hasPublicationYear "2020" @default.
• W3047983903 type Work @default.
• W3047983903 sameAs 3047983903 @default.
• W3047983903 citedByCount "4" @default.
• W3047983903 countsByYear W30479839032021 @default.
• W3047983903 countsByYear W30479839032022 @default.
• W3047983903 crossrefType "journal-article" @default.
• W3047983903 hasAuthorship W3047983903A5017069216 @default.
• W3047983903 hasAuthorship W3047983903A5041165007 @default.
• W3047983903 hasAuthorship W3047983903A5047413049 @default.
• W3047983903 hasAuthorship W3047983903A5052954776 @default.
• W3047983903 hasAuthorship W3047983903A5056870331 @default.
• W3047983903 hasAuthorship W3047983903A5057533296 @default.
• W3047983903 hasAuthorship W3047983903A5072115336 @default.
• W3047983903 hasAuthorship W3047983903A5077963098 @default.
• W3047983903 hasConcept C10205521 @default.
• W3047983903 hasConcept C104317684 @default.
• W3047983903 hasConcept C116716535 @default.
• W3047983903 hasConcept C145103041 @default.
• W3047983903 hasConcept C153911025 @default.
• W3047983903 hasConcept C170493617 @default.
• W3047983903 hasConcept C182704531 @default.
• W3047983903 hasConcept C185592680 @default.
• W3047983903 hasConcept C198826908 @default.
• W3047983903 hasConcept C2775960820 @default.
• W3047983903 hasConcept C2778279177 @default.
• W3047983903 hasConcept C28328180 @default.
• W3047983903 hasConcept C35496256 @default.
• W3047983903 hasConcept C55493867 @default.
• W3047983903 hasConcept C86803240 @default.
• W3047983903 hasConcept C95444343 @default.
• W3047983903 hasConceptScore W3047983903C10205521 @default.
• W3047983903 hasConceptScore W3047983903C104317684 @default.
• W3047983903 hasConceptScore W3047983903C116716535 @default.
• W3047983903 hasConceptScore W3047983903C145103041 @default.
• W3047983903 hasConceptScore W3047983903C153911025 @default.
• W3047983903 hasConceptScore W3047983903C170493617 @default.
• W3047983903 hasConceptScore W3047983903C182704531 @default.
• W3047983903 hasConceptScore W3047983903C185592680 @default.
• W3047983903 hasConceptScore W3047983903C198826908 @default.
• W3047983903 hasConceptScore W3047983903C2775960820 @default.
• W3047983903 hasConceptScore W3047983903C2778279177 @default.
• W3047983903 hasConceptScore W3047983903C28328180 @default.
• W3047983903 hasConceptScore W3047983903C35496256 @default.
• W3047983903 hasConceptScore W3047983903C55493867 @default.
• W3047983903 hasConceptScore W3047983903C86803240 @default.
• W3047983903 hasConceptScore W3047983903C95444343 @default.

• next