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- W3047994964 abstract "Basophils and mast cells (MCs) are important effector cells in the immune system. For a long time, it has been known that these cells can be activated though the cross-linking of IgE antibodies bound to their high-affinity receptor (FcεRI). However, evidence has accumulated suggesting that these cells can also be activated by various IgE-independent mechanisms. Occupation of MAS Related GPR Family Member X2 (MRGPRX2), a G protein-coupled receptor, is described as an alternative IgE-independent activation mechanism. Here we describe a flow cytometric technique to analyze MRGPRX2 expression and its functionality on cultured human MCs and conditioned basophils, that is, basophils with upregulated surface expression of MRGPRX2." @default.
- W3047994964 created "2020-08-13" @default.
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- W3047994964 date "2020-01-01" @default.
- W3047994964 modified "2023-09-25" @default.
- W3047994964 title "Measurement and Functional Analysis of the Mas-Related G Protein-Coupled Receptor MRGPRX2 on Human Mast Cells and Basophils" @default.
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- W3047994964 doi "https://doi.org/10.1007/978-1-0716-0696-4_18" @default.
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