Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048001511> ?p ?o ?g. }
- W3048001511 endingPage "111347" @default.
- W3048001511 startingPage "111347" @default.
- W3048001511 abstract "Optimizing scaffold architecture for perfect osteointegration depends on good understanding of bone ingrowth in the porous space of implants. This study developed an immunoregulatory agent-based model to discover the osteoinduction mechanism in porous scaffolds. Immunoreaction, macrophage polarization, and the corresponding growth factors were combined in the model, and all played critical roles in recruiting osteogenic cells that migrated into the scaffolds. Angiogenesis was also considered in this model. The bone ingrowth predicted by the model coincides with results from published in vivo experiments. Simulation results suggested that the pore architecture affected the diffusion process of chemotactic factors in the scaffolds, subsequently influencing the complex reactions of diverse cells and the osteoinduction location. In flexural pore spaces, bone formation spread from the periphery into the center of scaffolds due to larger M2 phenotype macrophage populations colonizing boundary regions and the distribution of corresponding growth factors concentration. In straight channels, osteogenic cells migrated further inward and osteoinduction initiated in deeper position as a result of the deeper distribution of osteogenic cytokines concentration field." @default.
- W3048001511 created "2020-08-13" @default.
- W3048001511 creator A5023597320 @default.
- W3048001511 creator A5023874610 @default.
- W3048001511 creator A5026270005 @default.
- W3048001511 creator A5049078993 @default.
- W3048001511 creator A5049981926 @default.
- W3048001511 creator A5050243724 @default.
- W3048001511 creator A5054821521 @default.
- W3048001511 creator A5059621509 @default.
- W3048001511 creator A5065209768 @default.
- W3048001511 date "2020-12-01" @default.
- W3048001511 modified "2023-10-16" @default.
- W3048001511 title "Modeling osteoinduction in titanium bone scaffold with a representative channel structure" @default.
- W3048001511 cites W1571775017 @default.
- W3048001511 cites W1757602702 @default.
- W3048001511 cites W1857671168 @default.
- W3048001511 cites W1964727874 @default.
- W3048001511 cites W1964733232 @default.
- W3048001511 cites W1979137563 @default.
- W3048001511 cites W1983635030 @default.
- W3048001511 cites W1986121492 @default.
- W3048001511 cites W1997794453 @default.
- W3048001511 cites W2002369319 @default.
- W3048001511 cites W2003899176 @default.
- W3048001511 cites W2004219315 @default.
- W3048001511 cites W2005877737 @default.
- W3048001511 cites W2020744745 @default.
- W3048001511 cites W2029523901 @default.
- W3048001511 cites W2031084334 @default.
- W3048001511 cites W2031728127 @default.
- W3048001511 cites W2035677810 @default.
- W3048001511 cites W2036177694 @default.
- W3048001511 cites W2036621935 @default.
- W3048001511 cites W2037716466 @default.
- W3048001511 cites W2041911911 @default.
- W3048001511 cites W2050875646 @default.
- W3048001511 cites W2053307155 @default.
- W3048001511 cites W2056318812 @default.
- W3048001511 cites W2059314287 @default.
- W3048001511 cites W2064705140 @default.
- W3048001511 cites W2080003269 @default.
- W3048001511 cites W2081106783 @default.
- W3048001511 cites W2086819694 @default.
- W3048001511 cites W2090763065 @default.
- W3048001511 cites W2091609802 @default.
- W3048001511 cites W2104904898 @default.
- W3048001511 cites W2113042424 @default.
- W3048001511 cites W2134208433 @default.
- W3048001511 cites W2138694950 @default.
- W3048001511 cites W2143892523 @default.
- W3048001511 cites W2144866485 @default.
- W3048001511 cites W2159210886 @default.
- W3048001511 cites W2159442019 @default.
- W3048001511 cites W2161590805 @default.
- W3048001511 cites W2180309502 @default.
- W3048001511 cites W2193505608 @default.
- W3048001511 cites W2414701500 @default.
- W3048001511 cites W2470932651 @default.
- W3048001511 cites W2474989629 @default.
- W3048001511 cites W2525558807 @default.
- W3048001511 cites W2580188336 @default.
- W3048001511 cites W2777717412 @default.
- W3048001511 cites W2790795972 @default.
- W3048001511 cites W2811493528 @default.
- W3048001511 cites W81993338 @default.
- W3048001511 doi "https://doi.org/10.1016/j.msec.2020.111347" @default.
- W3048001511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32919693" @default.
- W3048001511 hasPublicationYear "2020" @default.
- W3048001511 type Work @default.
- W3048001511 sameAs 3048001511 @default.
- W3048001511 citedByCount "9" @default.
- W3048001511 countsByYear W30480015112021 @default.
- W3048001511 countsByYear W30480015112022 @default.
- W3048001511 countsByYear W30480015112023 @default.
- W3048001511 crossrefType "journal-article" @default.
- W3048001511 hasAuthorship W3048001511A5023597320 @default.
- W3048001511 hasAuthorship W3048001511A5023874610 @default.
- W3048001511 hasAuthorship W3048001511A5026270005 @default.
- W3048001511 hasAuthorship W3048001511A5049078993 @default.
- W3048001511 hasAuthorship W3048001511A5049981926 @default.
- W3048001511 hasAuthorship W3048001511A5050243724 @default.
- W3048001511 hasAuthorship W3048001511A5054821521 @default.
- W3048001511 hasAuthorship W3048001511A5059621509 @default.
- W3048001511 hasAuthorship W3048001511A5065209768 @default.
- W3048001511 hasConcept C101414908 @default.
- W3048001511 hasConcept C105702510 @default.
- W3048001511 hasConcept C12554922 @default.
- W3048001511 hasConcept C127413603 @default.
- W3048001511 hasConcept C136229726 @default.
- W3048001511 hasConcept C141071460 @default.
- W3048001511 hasConcept C185592680 @default.
- W3048001511 hasConcept C192562407 @default.
- W3048001511 hasConcept C2780394083 @default.
- W3048001511 hasConcept C2781411149 @default.
- W3048001511 hasConcept C502942594 @default.
- W3048001511 hasConcept C71924100 @default.
- W3048001511 hasConcept C8337478 @default.