Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048002338> ?p ?o ?g. }
- W3048002338 endingPage "212" @default.
- W3048002338 startingPage "199" @default.
- W3048002338 abstract "Earlier we studied the copy number variations (CNVs) of ribosomal repeat (rDNA) and the satellite III fragment (1q12) (f-SatIII) in the cells of schizophrenia patients (SZ) and healthy controls (HC). In the present study we pursued two main objectives: (1) to confirm the increased rDNA and decreased f-SatIII content in the genomes of enlarged SZ and HC samples and (2) to compare the rDNA and f-SatIII content in the same DNA samples of SZ and HC individuals. We determined the rDNA CN and f-SatIII content in the genomes of leukocytes of 1770 subjects [HC (N = 814) and SZ (N = 956)]. Non-radioactive quantitative hybridization method (NQH) was applied for analysis of the various combinations of the two repeats sizes in SZ and HC groups. f-SatIII in human leukocytes (N = 1556) varies between 5.7 and 44.7 pg/ng DNA. RDNA CN varies between 200 and 896 (N = 1770). SZ group significantly differ from the HC group by lower f-SatIII content and by rDNA abundance. The f-SatIII and rDNA CN are not randomly combined in the genome. Higher rDNA CN values are associated with higher f-SatIII index values in SZ and HC. The f-SatIII variation interval in SZ group increases significantly in the subgroup with the high rDNA CN index values (>300 copies). Schizophrenia patients' genomes contain low number of f-SatIII copies corresponding with a large ribosomal repeats CN. A scheme is proposed to explain the low f-SatIII content in SZ group against the background of high rDNA CN." @default.
- W3048002338 created "2020-08-13" @default.
- W3048002338 creator A5000374537 @default.
- W3048002338 creator A5006655282 @default.
- W3048002338 creator A5014414692 @default.
- W3048002338 creator A5017906885 @default.
- W3048002338 creator A5031560265 @default.
- W3048002338 creator A5039131110 @default.
- W3048002338 creator A5045628122 @default.
- W3048002338 creator A5046604788 @default.
- W3048002338 creator A5052215573 @default.
- W3048002338 creator A5054405791 @default.
- W3048002338 creator A5078556885 @default.
- W3048002338 creator A5083951919 @default.
- W3048002338 creator A5087094815 @default.
- W3048002338 date "2020-09-01" @default.
- W3048002338 modified "2023-09-25" @default.
- W3048002338 title "Copy number variations of satellite III (1q12) and ribosomal repeats in health and schizophrenia" @default.
- W3048002338 cites W150738201 @default.
- W3048002338 cites W1763415643 @default.
- W3048002338 cites W1965456948 @default.
- W3048002338 cites W1969892080 @default.
- W3048002338 cites W1971999388 @default.
- W3048002338 cites W1973173192 @default.
- W3048002338 cites W1991799595 @default.
- W3048002338 cites W1992725371 @default.
- W3048002338 cites W1995259609 @default.
- W3048002338 cites W1998428497 @default.
- W3048002338 cites W2001773716 @default.
- W3048002338 cites W2006334511 @default.
- W3048002338 cites W2011816180 @default.
- W3048002338 cites W2013812415 @default.
- W3048002338 cites W2061481020 @default.
- W3048002338 cites W2063361808 @default.
- W3048002338 cites W2071061394 @default.
- W3048002338 cites W2074289572 @default.
- W3048002338 cites W2075427572 @default.
- W3048002338 cites W2079165897 @default.
- W3048002338 cites W2084159041 @default.
- W3048002338 cites W2092697706 @default.
- W3048002338 cites W2093385884 @default.
- W3048002338 cites W2096052762 @default.
- W3048002338 cites W2097822523 @default.
- W3048002338 cites W2102113193 @default.
- W3048002338 cites W2116753165 @default.
- W3048002338 cites W2124873881 @default.
- W3048002338 cites W2168713159 @default.
- W3048002338 cites W2210538740 @default.
- W3048002338 cites W2255688436 @default.
- W3048002338 cites W2334244908 @default.
- W3048002338 cites W2378703012 @default.
- W3048002338 cites W2513819772 @default.
- W3048002338 cites W2520837155 @default.
- W3048002338 cites W2560199361 @default.
- W3048002338 cites W2595675373 @default.
- W3048002338 cites W2606292401 @default.
- W3048002338 cites W2685599036 @default.
- W3048002338 cites W2734554375 @default.
- W3048002338 cites W2737227438 @default.
- W3048002338 cites W2751870612 @default.
- W3048002338 cites W2752681315 @default.
- W3048002338 cites W2757867913 @default.
- W3048002338 cites W2770153090 @default.
- W3048002338 cites W2775637572 @default.
- W3048002338 cites W2783564105 @default.
- W3048002338 cites W2786119759 @default.
- W3048002338 cites W2790208381 @default.
- W3048002338 cites W2791108199 @default.
- W3048002338 cites W2794594308 @default.
- W3048002338 cites W2801508060 @default.
- W3048002338 cites W2887986358 @default.
- W3048002338 cites W2902242691 @default.
- W3048002338 cites W2905151046 @default.
- W3048002338 cites W2949478542 @default.
- W3048002338 cites W2950928951 @default.
- W3048002338 cites W2958798177 @default.
- W3048002338 cites W2965429189 @default.
- W3048002338 cites W2977101232 @default.
- W3048002338 cites W2988891868 @default.
- W3048002338 cites W2989892565 @default.
- W3048002338 cites W3033426371 @default.
- W3048002338 doi "https://doi.org/10.1016/j.schres.2020.07.022" @default.
- W3048002338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32773342" @default.
- W3048002338 hasPublicationYear "2020" @default.
- W3048002338 type Work @default.
- W3048002338 sameAs 3048002338 @default.
- W3048002338 citedByCount "12" @default.
- W3048002338 countsByYear W30480023382021 @default.
- W3048002338 countsByYear W30480023382022 @default.
- W3048002338 countsByYear W30480023382023 @default.
- W3048002338 crossrefType "journal-article" @default.
- W3048002338 hasAuthorship W3048002338A5000374537 @default.
- W3048002338 hasAuthorship W3048002338A5006655282 @default.
- W3048002338 hasAuthorship W3048002338A5014414692 @default.
- W3048002338 hasAuthorship W3048002338A5017906885 @default.
- W3048002338 hasAuthorship W3048002338A5031560265 @default.
- W3048002338 hasAuthorship W3048002338A5039131110 @default.
- W3048002338 hasAuthorship W3048002338A5045628122 @default.