FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048005017> ?p ?o ?g. }

• W3048005017 endingPage "115167" @default.
• W3048005017 startingPage "115167" @default.
• W3048005017 abstract "Growing use of carbon nanotubes (CNTs) have garnered concerns regarding their association with adverse health effects. Few studies have probed how CNTs affect a host's susceptibility to pathogens, particularly respiratory viruses. We reported that exposure of lung cells and mice to pristine single-walled CNTs (SWCNTs) leads to significantly increased influenza virus H1N1 strain A/Mexico/4108/2009 (IAV) titers in concert with repressed antiviral immune responses. In the present study, we investigated if hydroxylated multi-walled CNTs (MWCNTs), would result in similar outcomes. C57BL/6 mice were exposed to 20 μg MWCNTs on day 0 and IAV on day 3 and samples were collected on day 7. We investigated pathological changes, viral titers, immune-related gene expression in lung tissue, and quantified differential cell counts and cytokine and chemokine levels in bronchoalveolar lavage fluid. MWCNTs alone caused mild inflammation with no apparent changes in immune markers whereas IAV alone presented typical infection-associated inflammation, pathology, and titers. The co-exposure (MWCNTs + IAV) did not alter titers or immune cell profiles compared to the IAV only but increased concentrations of IL-1β, TNFα, GM-CSF, KC, MIPs, and RANTES and inhibited mRNA expression of Tlr3, Rig-i, Mda5, and Ifit2. Our findings suggest MWCNTs modulate immune responses to IAV with no effect on the viral titer and modest pulmonary injury, a result different from those reported for SWCNT exposures. This is the first study to show that MWCNTs modify cytokine and chemokine responses that control aspects of host defenses which may play a greater role in mitigating IAV infections." @default.
• W3048005017 created "2020-08-13" @default.
• W3048005017 creator A5002073990 @default.
• W3048005017 creator A5006150039 @default.
• W3048005017 creator A5007364929 @default.
• W3048005017 creator A5027725855 @default.
• W3048005017 creator A5029941683 @default.
• W3048005017 creator A5034404846 @default.
• W3048005017 creator A5037847608 @default.
• W3048005017 creator A5045475216 @default.
• W3048005017 creator A5046012473 @default.
• W3048005017 creator A5057185566 @default.
• W3048005017 creator A5072881070 @default.
• W3048005017 date "2020-10-01" @default.
• W3048005017 modified "2023-10-09" @default.
• W3048005017 title "Hydroxyl functionalized multi-walled carbon nanotubes modulate immune responses without increasing 2009 pandemic influenza A/H1N1 virus titers in infected mice" @default.
• W3048005017 cites W1979514172 @default.
• W3048005017 cites W1980006807 @default.
• W3048005017 cites W1981013578 @default.
• W3048005017 cites W1982210364 @default.
• W3048005017 cites W1986675275 @default.
• W3048005017 cites W1988457962 @default.
• W3048005017 cites W1990437594 @default.
• W3048005017 cites W2006175524 @default.
• W3048005017 cites W2009207411 @default.
• W3048005017 cites W2018752202 @default.
• W3048005017 cites W2020283857 @default.
• W3048005017 cites W2029445495 @default.
• W3048005017 cites W2037306255 @default.
• W3048005017 cites W2043302934 @default.
• W3048005017 cites W2043738478 @default.
• W3048005017 cites W2046315474 @default.
• W3048005017 cites W2052572105 @default.
• W3048005017 cites W2053480560 @default.
• W3048005017 cites W2063310879 @default.
• W3048005017 cites W2069608579 @default.
• W3048005017 cites W2087742285 @default.
• W3048005017 cites W2089929841 @default.
• W3048005017 cites W2092604966 @default.
• W3048005017 cites W2099717039 @default.
• W3048005017 cites W2100452343 @default.
• W3048005017 cites W2101183319 @default.
• W3048005017 cites W2107277218 @default.
• W3048005017 cites W2115222450 @default.
• W3048005017 cites W2117243999 @default.
• W3048005017 cites W2119229440 @default.
• W3048005017 cites W2126864422 @default.
• W3048005017 cites W2128976939 @default.
• W3048005017 cites W2128994536 @default.
• W3048005017 cites W2129906907 @default.
• W3048005017 cites W2130406156 @default.
• W3048005017 cites W2131621090 @default.
• W3048005017 cites W2134132503 @default.
• W3048005017 cites W2134725315 @default.
• W3048005017 cites W2138366706 @default.
• W3048005017 cites W2149234262 @default.
• W3048005017 cites W2152842365 @default.
• W3048005017 cites W2159904710 @default.
• W3048005017 cites W2165987864 @default.
• W3048005017 cites W2175478450 @default.
• W3048005017 cites W2256756668 @default.
• W3048005017 cites W2268895855 @default.
• W3048005017 cites W2288283095 @default.
• W3048005017 cites W2319106429 @default.
• W3048005017 cites W2328719838 @default.
• W3048005017 cites W2419193777 @default.
• W3048005017 cites W2569078601 @default.
• W3048005017 cites W2577289261 @default.
• W3048005017 cites W2611856985 @default.
• W3048005017 cites W2767517742 @default.
• W3048005017 cites W2775755403 @default.
• W3048005017 cites W2779432512 @default.
• W3048005017 cites W2794800757 @default.
• W3048005017 cites W2810837670 @default.
• W3048005017 cites W2887511408 @default.
• W3048005017 cites W2941994989 @default.
• W3048005017 cites W2962936421 @default.
• W3048005017 doi "https://doi.org/10.1016/j.taap.2020.115167" @default.
• W3048005017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32771490" @default.
• W3048005017 hasPublicationYear "2020" @default.
• W3048005017 type Work @default.
• W3048005017 sameAs 3048005017 @default.
• W3048005017 citedByCount "6" @default.
• W3048005017 countsByYear W30480050172021 @default.
• W3048005017 countsByYear W30480050172023 @default.
• W3048005017 crossrefType "journal-article" @default.
• W3048005017 hasAuthorship W3048005017A5002073990 @default.
• W3048005017 hasAuthorship W3048005017A5006150039 @default.
• W3048005017 hasAuthorship W3048005017A5007364929 @default.
• W3048005017 hasAuthorship W3048005017A5027725855 @default.
• W3048005017 hasAuthorship W3048005017A5029941683 @default.
• W3048005017 hasAuthorship W3048005017A5034404846 @default.
• W3048005017 hasAuthorship W3048005017A5037847608 @default.
• W3048005017 hasAuthorship W3048005017A5045475216 @default.
• W3048005017 hasAuthorship W3048005017A5046012473 @default.
• W3048005017 hasAuthorship W3048005017A5057185566 @default.
• W3048005017 hasAuthorship W3048005017A5072881070 @default.
• W3048005017 hasConcept C126322002 @default.

• next