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• W3048005303 abstract "PPARD has been suggested to contribute to the etiology of schizophrenia (SCZ) with the underlying mechanisms largely unknown. Here, we first collected and analyzed the PPARD expression profile from three groups: (1) 18 healthy control (HC) subjects, (2) 14 clinical high-risk (CHR) patients, and (3) 19 early onset of SCZ (EOS) patients. After that, we conducted a systematical pathway analysis to explore the potential mechanisms involved in PPARD exerting influence on the pathological development of SCZ. Compared to the HC group, the expression of PPARD was slightly decreased in the EOS group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mtext>LFC</mml:mtext><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.34</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.23</mml:mn></mml:math>) and increased in the CHR group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mtext>LFC</mml:mtext><mml:mo>=</mml:mo><mml:mn>0.65</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.20</mml:mn></mml:math>). However, there was a significant difference between the EOS group and the CHR group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mtext>LFC</mml:mtext><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.99</mml:mn></mml:math>; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.015</mml:mn></mml:math>), reflecting the amount of variation in PPARD expression before and after the onset of SCZ. Pathway analysis suggested that overexpression of PPARD may regulate ten proteins or molecules to inhibit the pathological development of SCZ, including the deactivation of eight SCZ promoters and stimulation of two SCZ inhibitors. Our results support the association between PPARD and SCZ. The pathways identified may help in the understanding of the potential mechanisms by which PPARD contributes to the etiology of SCZ." @default.
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• W3048005303 date "2020-08-07" @default.
• W3048005303 modified "2023-10-15" @default.
• W3048005303 title "PPARD May Play a Protective Role against the Development of Schizophrenia" @default.
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• W3048005303 doi "https://doi.org/10.1155/2020/3480412" @default.
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