Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048007768> ?p ?o ?g. }
- W3048007768 abstract "Abstract Understanding kinetic control of biological processes is as important as identifying components that constitute pathways. Insulin-signaling (IS) is central for almost all metazoans and its perturbations are associated with various diseases and aging. While temporal phosphorylation changes and kinetic constants have provided some insights, constant or variable parameters that establish and maintain signal topology are poorly understood. Our iterative experimental and mathematical simulation-based approaches reveal novel kinetic parameters that encode concentration and nutrient dependent information. Further, we find that pulsatile fasting insulin rewires IS akin to memory and in anticipation of a fed response. Importantly, selective kinetic gating of signals and maximum connectivity, between metabolic and growth-factor arms under normo-insulinemic states, maintains network topology. In addition to unraveling kinetic constraints that determine cascade architecture, our findings will help in identifying novel therapeutic strategies that conserve coupling between metabolic and growth-factor arms, which is lost in diseases and conditions of hyperinsulinemia." @default.
- W3048007768 created "2020-08-13" @default.
- W3048007768 creator A5006512551 @default.
- W3048007768 creator A5035253880 @default.
- W3048007768 creator A5069396236 @default.
- W3048007768 creator A5074154848 @default.
- W3048007768 date "2020-08-10" @default.
- W3048007768 modified "2023-10-15" @default.
- W3048007768 title "Continuous variable response, kinetic gating and connectivity that govern IS topology are perturbed in hyperinsulinemia" @default.
- W3048007768 cites W1490956705 @default.
- W3048007768 cites W1502440948 @default.
- W3048007768 cites W1964095953 @default.
- W3048007768 cites W1965435094 @default.
- W3048007768 cites W1966133006 @default.
- W3048007768 cites W1968442152 @default.
- W3048007768 cites W1976696678 @default.
- W3048007768 cites W1998203489 @default.
- W3048007768 cites W2005390559 @default.
- W3048007768 cites W2014482569 @default.
- W3048007768 cites W2014887370 @default.
- W3048007768 cites W2018435536 @default.
- W3048007768 cites W2042321087 @default.
- W3048007768 cites W2056085420 @default.
- W3048007768 cites W2061180659 @default.
- W3048007768 cites W2065417819 @default.
- W3048007768 cites W2066659565 @default.
- W3048007768 cites W2074076323 @default.
- W3048007768 cites W2081608955 @default.
- W3048007768 cites W2090300920 @default.
- W3048007768 cites W2094166298 @default.
- W3048007768 cites W2100486339 @default.
- W3048007768 cites W2104303958 @default.
- W3048007768 cites W2104768673 @default.
- W3048007768 cites W2107186290 @default.
- W3048007768 cites W2109067263 @default.
- W3048007768 cites W2110690451 @default.
- W3048007768 cites W2111184079 @default.
- W3048007768 cites W2115337061 @default.
- W3048007768 cites W2116235994 @default.
- W3048007768 cites W2121103946 @default.
- W3048007768 cites W2129565951 @default.
- W3048007768 cites W2136179119 @default.
- W3048007768 cites W2141977920 @default.
- W3048007768 cites W2144323242 @default.
- W3048007768 cites W2147387884 @default.
- W3048007768 cites W2149182211 @default.
- W3048007768 cites W2149199536 @default.
- W3048007768 cites W2152377123 @default.
- W3048007768 cites W2155418451 @default.
- W3048007768 cites W2165708858 @default.
- W3048007768 cites W2292498868 @default.
- W3048007768 cites W2336304679 @default.
- W3048007768 cites W2345593561 @default.
- W3048007768 cites W2412157005 @default.
- W3048007768 cites W2520198892 @default.
- W3048007768 cites W2528271650 @default.
- W3048007768 cites W2606513998 @default.
- W3048007768 cites W2609951214 @default.
- W3048007768 cites W2745326990 @default.
- W3048007768 cites W2763635492 @default.
- W3048007768 cites W2792246690 @default.
- W3048007768 cites W2810748300 @default.
- W3048007768 cites W2886865853 @default.
- W3048007768 cites W2916211599 @default.
- W3048007768 cites W2983828103 @default.
- W3048007768 cites W3011004979 @default.
- W3048007768 cites W3037634030 @default.
- W3048007768 cites W4238567307 @default.
- W3048007768 doi "https://doi.org/10.1101/2020.08.10.243675" @default.
- W3048007768 hasPublicationYear "2020" @default.
- W3048007768 type Work @default.
- W3048007768 sameAs 3048007768 @default.
- W3048007768 citedByCount "0" @default.
- W3048007768 crossrefType "posted-content" @default.
- W3048007768 hasAuthorship W3048007768A5006512551 @default.
- W3048007768 hasAuthorship W3048007768A5035253880 @default.
- W3048007768 hasAuthorship W3048007768A5069396236 @default.
- W3048007768 hasAuthorship W3048007768A5074154848 @default.
- W3048007768 hasBestOaLocation W30480077681 @default.
- W3048007768 hasConcept C114614502 @default.
- W3048007768 hasConcept C121332964 @default.
- W3048007768 hasConcept C134018914 @default.
- W3048007768 hasConcept C135889238 @default.
- W3048007768 hasConcept C154945302 @default.
- W3048007768 hasConcept C169760540 @default.
- W3048007768 hasConcept C176777502 @default.
- W3048007768 hasConcept C184720557 @default.
- W3048007768 hasConcept C186060115 @default.
- W3048007768 hasConcept C194544171 @default.
- W3048007768 hasConcept C2777391703 @default.
- W3048007768 hasConcept C2779306644 @default.
- W3048007768 hasConcept C2780988686 @default.
- W3048007768 hasConcept C33923547 @default.
- W3048007768 hasConcept C41008148 @default.
- W3048007768 hasConcept C62520636 @default.
- W3048007768 hasConcept C86803240 @default.
- W3048007768 hasConceptScore W3048007768C114614502 @default.
- W3048007768 hasConceptScore W3048007768C121332964 @default.
- W3048007768 hasConceptScore W3048007768C134018914 @default.
- W3048007768 hasConceptScore W3048007768C135889238 @default.