Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048008947> ?p ?o ?g. }
- W3048008947 endingPage "655" @default.
- W3048008947 startingPage "649" @default.
- W3048008947 abstract "DNA-encoded library (DEL) technology enables rapid, economical synthesis, and exploration of novel chemical space. Reaction development for DEL synthesis has recently accelerated in pace with a specific emphasis on ensuring that the reaction does not compromise the integrity of the encoding DNA. However, the factors that contribute to a reaction's compatibility remain relatively unknown. We investigated several solid-phase reactions and encoding conditions and determined their impact on DNA compatibility. Conditions that minimized the accessibility of reactive groups on the DNA encoding tag (switching solvent, low temperature, double-stranded encoding tag) significantly improved compatibility. We showcased this approach in the multistep synthesis of an acyldepsipeptide (ADEP1) fragment, which preserved 73% of DNA for a >100-fold improvement over canonical conditions. These results are particularly encouraging in the context of multistep reaction sequences to access natural product-like scaffolds and more broadly underscore the importance of reconciling the biophysical properties and reactivity of DNA with chemistry development to yield high-quality libraries of those scaffolds." @default.
- W3048008947 created "2020-08-13" @default.
- W3048008947 creator A5015679090 @default.
- W3048008947 creator A5018062150 @default.
- W3048008947 date "2020-08-06" @default.
- W3048008947 modified "2023-09-23" @default.
- W3048008947 title "Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis" @default.
- W3048008947 cites W1119367842 @default.
- W3048008947 cites W1160365437 @default.
- W3048008947 cites W1968642113 @default.
- W3048008947 cites W1968753037 @default.
- W3048008947 cites W1980687891 @default.
- W3048008947 cites W1982796443 @default.
- W3048008947 cites W1985278607 @default.
- W3048008947 cites W1987929665 @default.
- W3048008947 cites W1997688868 @default.
- W3048008947 cites W2000737613 @default.
- W3048008947 cites W2004360551 @default.
- W3048008947 cites W2017423606 @default.
- W3048008947 cites W2021430271 @default.
- W3048008947 cites W2023003030 @default.
- W3048008947 cites W2029209483 @default.
- W3048008947 cites W2055286910 @default.
- W3048008947 cites W2088952397 @default.
- W3048008947 cites W2124555115 @default.
- W3048008947 cites W2163562422 @default.
- W3048008947 cites W2165278773 @default.
- W3048008947 cites W2166602500 @default.
- W3048008947 cites W2270090559 @default.
- W3048008947 cites W2299985318 @default.
- W3048008947 cites W2331108854 @default.
- W3048008947 cites W2401913982 @default.
- W3048008947 cites W2584580415 @default.
- W3048008947 cites W2588529552 @default.
- W3048008947 cites W2592709654 @default.
- W3048008947 cites W2595526189 @default.
- W3048008947 cites W2734926677 @default.
- W3048008947 cites W2760277192 @default.
- W3048008947 cites W2810724953 @default.
- W3048008947 cites W2913261199 @default.
- W3048008947 cites W2914741201 @default.
- W3048008947 cites W2917836509 @default.
- W3048008947 cites W2921000810 @default.
- W3048008947 cites W2928359543 @default.
- W3048008947 cites W2937482900 @default.
- W3048008947 cites W2947079937 @default.
- W3048008947 cites W2949291891 @default.
- W3048008947 cites W2969846984 @default.
- W3048008947 cites W2982660402 @default.
- W3048008947 cites W2996462586 @default.
- W3048008947 cites W3006404080 @default.
- W3048008947 cites W4232801421 @default.
- W3048008947 cites W589574422 @default.
- W3048008947 doi "https://doi.org/10.1021/acscombsci.0c00101" @default.
- W3048008947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7655546" @default.
- W3048008947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32786319" @default.
- W3048008947 hasPublicationYear "2020" @default.
- W3048008947 type Work @default.
- W3048008947 sameAs 3048008947 @default.
- W3048008947 citedByCount "0" @default.
- W3048008947 crossrefType "journal-article" @default.
- W3048008947 hasAuthorship W3048008947A5015679090 @default.
- W3048008947 hasAuthorship W3048008947A5018062150 @default.
- W3048008947 hasBestOaLocation W30480089472 @default.
- W3048008947 hasConcept C171250308 @default.
- W3048008947 hasConcept C178790620 @default.
- W3048008947 hasConcept C185592680 @default.
- W3048008947 hasConcept C192562407 @default.
- W3048008947 hasConcept C21951064 @default.
- W3048008947 hasConcept C2776469878 @default.
- W3048008947 hasConcept C2779281246 @default.
- W3048008947 hasConcept C44280652 @default.
- W3048008947 hasConcept C552990157 @default.
- W3048008947 hasConcept C55493867 @default.
- W3048008947 hasConcept C64241487 @default.
- W3048008947 hasConcept C70721500 @default.
- W3048008947 hasConcept C86803240 @default.
- W3048008947 hasConceptScore W3048008947C171250308 @default.
- W3048008947 hasConceptScore W3048008947C178790620 @default.
- W3048008947 hasConceptScore W3048008947C185592680 @default.
- W3048008947 hasConceptScore W3048008947C192562407 @default.
- W3048008947 hasConceptScore W3048008947C21951064 @default.
- W3048008947 hasConceptScore W3048008947C2776469878 @default.
- W3048008947 hasConceptScore W3048008947C2779281246 @default.
- W3048008947 hasConceptScore W3048008947C44280652 @default.
- W3048008947 hasConceptScore W3048008947C552990157 @default.
- W3048008947 hasConceptScore W3048008947C55493867 @default.
- W3048008947 hasConceptScore W3048008947C64241487 @default.
- W3048008947 hasConceptScore W3048008947C70721500 @default.
- W3048008947 hasConceptScore W3048008947C86803240 @default.
- W3048008947 hasFunder F4320337354 @default.
- W3048008947 hasFunder F4320337355 @default.
- W3048008947 hasIssue "11" @default.
- W3048008947 hasLocation W30480089471 @default.
- W3048008947 hasLocation W30480089472 @default.
- W3048008947 hasLocation W30480089473 @default.
- W3048008947 hasOpenAccess W3048008947 @default.
- W3048008947 hasPrimaryLocation W30480089471 @default.