FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048014252> ?p ?o ?g. }

• W3048014252 endingPage "1255" @default.
• W3048014252 startingPage "1247" @default.
• W3048014252 abstract "Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets, resulting in insulin deficiency—often begins early in life when islet autoantibody appearance signals high risk1. However, clinical diabetes can follow in weeks or only after decades, and is very difficult to predict. Ketoacidosis at onset remains common2,3 and is most severe in the very young4,5, in whom it can be life threatening and difficult to treat6–9. Autoantibody surveillance programs effectively prevent most ketoacidosis10–12 but require frequent evaluations whose expense limits public health adoption13. Prevention therapies applied before onset, when greater islet mass remains, have rarely been feasible14 because individuals at greatest risk of impending T1D are difficult to identify. To remedy this, we sought accurate, cost-effective estimation of future T1D risk by developing a combined risk score incorporating both fixed and variable factors (genetic, clinical and immunological) in 7,798 high-risk children followed closely from birth for 9.3 years. Compared with autoantibodies alone, the combined model dramatically improves T1D prediction at ≥2 years of age over horizons up to 8 years of age (area under the receiver operating characteristic curve ≥ 0.9), doubles the estimated efficiency of population-based newborn screening to prevent ketoacidosis, and enables individualized risk estimates for better prevention trial selection. In a study of children with high genetic risk aged 2 years or older, a risk score integrating pancreatic islet autoantibodies, genetic factors and family history is highly predictive of type 1 diabetes in the subsequent 8 years." @default.
• W3048014252 created "2020-08-13" @default.
• W3048014252 creator A5007656583 @default.
• W3048014252 creator A5008841181 @default.
• W3048014252 creator A5034030410 @default.
• W3048014252 creator A5046281941 @default.
• W3048014252 creator A5050470241 @default.
• W3048014252 creator A5052398139 @default.
• W3048014252 creator A5056102795 @default.
• W3048014252 creator A5056977453 @default.
• W3048014252 creator A5058889710 @default.
• W3048014252 creator A5062338037 @default.
• W3048014252 creator A5070735232 @default.
• W3048014252 creator A5084625995 @default.
• W3048014252 creator A5087453912 @default.
• W3048014252 date "2020-08-01" @default.
• W3048014252 modified "2023-10-17" @default.
• W3048014252 title "A combined risk score enhances prediction of type 1 diabetes among susceptible children" @default.
• W3048014252 cites W1208569767 @default.
• W3048014252 cites W1468392017 @default.
• W3048014252 cites W1513618424 @default.
• W3048014252 cites W1681932403 @default.
• W3048014252 cites W1965800980 @default.
• W3048014252 cites W1967736782 @default.
• W3048014252 cites W1985288159 @default.
• W3048014252 cites W1986160442 @default.
• W3048014252 cites W1987993086 @default.
• W3048014252 cites W1990514655 @default.
• W3048014252 cites W2000272384 @default.
• W3048014252 cites W2014646415 @default.
• W3048014252 cites W2020153135 @default.
• W3048014252 cites W2021458291 @default.
• W3048014252 cites W2027624649 @default.
• W3048014252 cites W2031364732 @default.
• W3048014252 cites W2051883261 @default.
• W3048014252 cites W2058568793 @default.
• W3048014252 cites W2083616093 @default.
• W3048014252 cites W2091966657 @default.
• W3048014252 cites W2095256598 @default.
• W3048014252 cites W2096485353 @default.
• W3048014252 cites W2099424483 @default.
• W3048014252 cites W2104258246 @default.
• W3048014252 cites W2114586150 @default.
• W3048014252 cites W2124112243 @default.
• W3048014252 cites W2126288005 @default.
• W3048014252 cites W2129044010 @default.
• W3048014252 cites W2131249054 @default.
• W3048014252 cites W2138740885 @default.
• W3048014252 cites W2145678477 @default.
• W3048014252 cites W2148593614 @default.
• W3048014252 cites W2155063253 @default.
• W3048014252 cites W2160344431 @default.
• W3048014252 cites W2161871220 @default.
• W3048014252 cites W2171825365 @default.
• W3048014252 cites W2179026698 @default.
• W3048014252 cites W2257801984 @default.
• W3048014252 cites W2277933781 @default.
• W3048014252 cites W2403952208 @default.
• W3048014252 cites W2410293149 @default.
• W3048014252 cites W2414611233 @default.
• W3048014252 cites W2416473596 @default.
• W3048014252 cites W2418768392 @default.
• W3048014252 cites W2471466179 @default.
• W3048014252 cites W2474483842 @default.
• W3048014252 cites W2618596952 @default.
• W3048014252 cites W2657531641 @default.
• W3048014252 cites W2766351669 @default.
• W3048014252 cites W2789784269 @default.
• W3048014252 cites W2795575996 @default.
• W3048014252 cites W2803462035 @default.
• W3048014252 cites W2862866264 @default.
• W3048014252 cites W2895448611 @default.
• W3048014252 cites W2897531212 @default.
• W3048014252 cites W2901709342 @default.
• W3048014252 cites W2909206924 @default.
• W3048014252 cites W2909847496 @default.
• W3048014252 cites W2939526051 @default.
• W3048014252 cites W2979632589 @default.
• W3048014252 cites W3140117102 @default.
• W3048014252 cites W3151675209 @default.
• W3048014252 cites W4213167025 @default.
• W3048014252 cites W4214512856 @default.
• W3048014252 cites W4239330499 @default.
• W3048014252 cites W4256482967 @default.
• W3048014252 cites W4290622918 @default.
• W3048014252 cites W4297957478 @default.
• W3048014252 cites W4386007683 @default.
• W3048014252 doi "https://doi.org/10.1038/s41591-020-0930-4" @default.
• W3048014252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7556983" @default.
• W3048014252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32770166" @default.
• W3048014252 hasPublicationYear "2020" @default.
• W3048014252 type Work @default.
• W3048014252 sameAs 3048014252 @default.
• W3048014252 citedByCount "72" @default.
• W3048014252 countsByYear W30480142522020 @default.
• W3048014252 countsByYear W30480142522021 @default.
• W3048014252 countsByYear W30480142522022 @default.
• W3048014252 countsByYear W30480142522023 @default.

• next