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• W3048015387 endingPage "101981" @default.
• W3048015387 startingPage "101981" @default.
• W3048015387 abstract "The study revolves around synthesizing stimuli-responsive drug-polymer conjugate of Gemcitabine hydrochloride and PNIPAAm-co-AAc and to investigate the delivery of Gemcitabine to cancerous cells by the formulation of stimuli-responsive Gem-conjugate. Gemcitabine HCl conjugated to a thermoresponsive polymer was undergone through the amine group at the N4 position of Gemcitabine hydrochloride linked with the carboxylic group of the stimuli-responsive polymer, leading to the construction of amide linkage amongst the drug and polymer. The subsequent Gem-conjugate was characterized by several analytical methods viz. Elemental, DSC, TGA, XRD, FESEM, TEM, DLS and 1H NMR. Finally, in vitro cytotoxicity assay was carried out on Panc-1 cancer cell lines. The prepared stimuli-responsive Gemcitabine nanoconjugate was found to be 55.05 nm in size with a capacity to release 80.72% drug over a period of 24 h in a medium of pH 5.0 following Fickian release kinetics. The cytotoxicity assay revealed that nanoconjugate notably inhibited the growth of Panc-1 cells compared to the free drug in a dose-dependent manner. The CLSM study revealed that Gem-conjugate induces more apoptosis to Panc-1 cell as compared to the native drug. The stimuli-responsive nano conjugate was found stable at 25 °C in dark environment. Overall, the data suggest that Gemcitabine HCl conjugated to a stimuli-responsive polymer can intensify the delivery of Gemcitabine to Panc-1 cancer cell lines, which might hold substantially proven potential in the treatment pancreatic cancer. The conjugate holds an alternative direction for further applications of Gemcitabine hydrochloride." @default.
• W3048015387 created "2020-08-13" @default.
• W3048015387 creator A5031893447 @default.
• W3048015387 creator A5061170602 @default.
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• W3048015387 date "2020-12-01" @default.
• W3048015387 modified "2023-10-13" @default.
• W3048015387 title "Targeting Gemcitabine hydrochloride to tumor microenvironment through stimuli-responsive Nano-conjugate: Synthesis, characterization, and in vitro assessment" @default.
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• W3048015387 doi "https://doi.org/10.1016/j.jddst.2020.101981" @default.
• W3048015387 hasPublicationYear "2020" @default.
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