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• W3048019355 endingPage "e9659" @default.
• W3048019355 startingPage "e9659" @default.
• W3048019355 abstract "Mycobacterium ulcerans is the causative agent of a debilitating skin and soft tissue infection known as Buruli ulcer (BU). There is no vaccine against BU. The purpose of this study was to investigate the vaccine potential of two previously described immunogenic M. ulcerans proteins, MUL_3720 and Hsp18, using a mouse tail infection model of BU.Recombinant versions of the two proteins were each electrostatically coupled with a previously described lipopeptide adjuvant. Seven C57BL/6 and seven BALB/c mice were vaccinated and boosted with each of the formulations. Vaccinated mice were then challenged with M. ulcerans via subcutaneous tail inoculation. Vaccine performance was assessed by time-to-ulceration compared to unvaccinated mice.The MUL_3720 and Hsp18 vaccines induced high titres of antigen-specific antibodies that were predominately subtype IgG1. However, all mice developed ulcers by day-40 post-M. ulcerans challenge. No significant difference was observed in the time-to-onset of ulceration between the experimental vaccine groups and unvaccinated animals.These data align with previous vaccine experiments using Hsp18 and MUL_3720 that indicated these proteins may not be appropriate vaccine antigens. This work highlights the need to explore alternative vaccine targets and different approaches to understand the role antibodies might play in controlling BU." @default.
• W3048019355 created "2020-08-13" @default.
• W3048019355 creator A5002414807 @default.
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• W3048019355 creator A5024915258 @default.
• W3048019355 creator A5034750391 @default.
• W3048019355 creator A5035122969 @default.
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• W3048019355 creator A5063816402 @default.
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• W3048019355 date "2020-08-07" @default.
• W3048019355 modified "2023-09-30" @default.
• W3048019355 title "High antibody titres induced by protein subunit vaccines using<i>Mycobacterium ulcerans</i>antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice" @default.
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