Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048032056> ?p ?o ?g. }
- W3048032056 abstract "Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson’s disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either with small molecule kinase inhibitors or anti-sense oligonucleotides, have recently advanced to the clinic. Historically, there have been few successes in the development of therapies that might slow or halt the progression of neurodegenerative diseases. Over the past few decades of biomedical research, retrospective analyses suggest the broad integration of informative biomarkers early in development tends to distinguish successful pipelines from those that fail early. Herein, we discuss the biomarker regulatory process, emerging LRRK2 biomarker candidates, assays, underlying biomarker biology, and clinical integration." @default.
- W3048032056 created "2020-08-13" @default.
- W3048032056 creator A5071278272 @default.
- W3048032056 creator A5090488994 @default.
- W3048032056 date "2020-08-06" @default.
- W3048032056 modified "2023-10-16" @default.
- W3048032056 title "Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics" @default.
- W3048032056 cites W1544196343 @default.
- W3048032056 cites W1951215936 @default.
- W3048032056 cites W1964914409 @default.
- W3048032056 cites W1967900265 @default.
- W3048032056 cites W1969049244 @default.
- W3048032056 cites W1977391806 @default.
- W3048032056 cites W1977792921 @default.
- W3048032056 cites W1981704961 @default.
- W3048032056 cites W1981872612 @default.
- W3048032056 cites W1986961354 @default.
- W3048032056 cites W1991884446 @default.
- W3048032056 cites W1997188614 @default.
- W3048032056 cites W1999387506 @default.
- W3048032056 cites W2004536040 @default.
- W3048032056 cites W2017906219 @default.
- W3048032056 cites W2022483806 @default.
- W3048032056 cites W2027834423 @default.
- W3048032056 cites W2031031932 @default.
- W3048032056 cites W2032061955 @default.
- W3048032056 cites W2034196705 @default.
- W3048032056 cites W2040696002 @default.
- W3048032056 cites W2054956841 @default.
- W3048032056 cites W2058298068 @default.
- W3048032056 cites W2062065799 @default.
- W3048032056 cites W2063127941 @default.
- W3048032056 cites W2067013656 @default.
- W3048032056 cites W2070386521 @default.
- W3048032056 cites W2071318427 @default.
- W3048032056 cites W2072529095 @default.
- W3048032056 cites W2074370114 @default.
- W3048032056 cites W2076108181 @default.
- W3048032056 cites W2076888837 @default.
- W3048032056 cites W2077047479 @default.
- W3048032056 cites W2085701543 @default.
- W3048032056 cites W2090804804 @default.
- W3048032056 cites W2100894616 @default.
- W3048032056 cites W2103205889 @default.
- W3048032056 cites W2103454698 @default.
- W3048032056 cites W2107153099 @default.
- W3048032056 cites W2110157421 @default.
- W3048032056 cites W2113518091 @default.
- W3048032056 cites W2120682296 @default.
- W3048032056 cites W2121516058 @default.
- W3048032056 cites W2124681346 @default.
- W3048032056 cites W2124906403 @default.
- W3048032056 cites W2128184553 @default.
- W3048032056 cites W2130444809 @default.
- W3048032056 cites W2134829539 @default.
- W3048032056 cites W2136216054 @default.
- W3048032056 cites W2143548516 @default.
- W3048032056 cites W2144668530 @default.
- W3048032056 cites W2145896896 @default.
- W3048032056 cites W2152874097 @default.
- W3048032056 cites W2161392725 @default.
- W3048032056 cites W2170146596 @default.
- W3048032056 cites W2174927436 @default.
- W3048032056 cites W2228972256 @default.
- W3048032056 cites W2253950023 @default.
- W3048032056 cites W2272666074 @default.
- W3048032056 cites W2285028136 @default.
- W3048032056 cites W2295939659 @default.
- W3048032056 cites W2338556452 @default.
- W3048032056 cites W2396649694 @default.
- W3048032056 cites W2480556520 @default.
- W3048032056 cites W2496954959 @default.
- W3048032056 cites W2520855151 @default.
- W3048032056 cites W2523584888 @default.
- W3048032056 cites W2593373447 @default.
- W3048032056 cites W2618120805 @default.
- W3048032056 cites W2742044901 @default.
- W3048032056 cites W2749825835 @default.
- W3048032056 cites W2769156514 @default.
- W3048032056 cites W2781504634 @default.
- W3048032056 cites W2781674541 @default.
- W3048032056 cites W2783569768 @default.
- W3048032056 cites W2789816271 @default.
- W3048032056 cites W2801497388 @default.
- W3048032056 cites W2884363644 @default.
- W3048032056 cites W2907560574 @default.
- W3048032056 cites W2917353757 @default.
- W3048032056 cites W2921348596 @default.
- W3048032056 cites W2944466104 @default.
- W3048032056 cites W2949785308 @default.
- W3048032056 cites W2984229501 @default.
- W3048032056 cites W3003392730 @default.
- W3048032056 cites W3019998570 @default.
- W3048032056 cites W3028324043 @default.
- W3048032056 cites W3103507482 @default.
- W3048032056 cites W3172077004 @default.
- W3048032056 cites W91108901 @default.
- W3048032056 doi "https://doi.org/10.3389/fnins.2020.00807" @default.
- W3048032056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7438883" @default.
- W3048032056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32903744" @default.