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- W3048082123 abstract "Abstract Duplication of mammalian genomes requires replisomes to overcome numerous impediments during passage through open (eu) and condensed (hetero) chromatin. Typically, studies of replication stress characterize mixed populations of challenged and unchallenged replication forks, averaged across S phase, and model a single species of “stressed” replisome. Here, in cells containing potent obstacles to replication, we find two different lesion proximal replisomes. One is bound by the DONSON protein and is more frequent in early S phase, in regions marked by euchromatin. The other interacts with the FANCM DNA translocase, is more prominent in late S phase, and favors heterochromatin. The two forms can also be detected in unstressed cells. ChIP-seq of DNA associated with DONSON or FANCM confirms the bias of the former towards regions that replicate early and the skew of the latter towards regions that replicate late." @default.
- W3048082123 created "2020-08-13" @default.
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- W3048082123 date "2020-08-07" @default.
- W3048082123 modified "2023-10-10" @default.
- W3048082123 title "DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain" @default.
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- W3048082123 doi "https://doi.org/10.1038/s41467-020-17449-1" @default.
- W3048082123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7414851" @default.
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