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- W3048097962 abstract "Trastuzumab (Herceptin ® , Roche) completely revolutionized the outcome of patients with HER2-positive breast cancer, in the metastatic, adjuvant and neoadjuvant setting. However, acquired resistances appear mostly, whose potential mechanisms are multiple. Two agents recently appeared: pertuzumab (Perjeta ® , Roche) and T-DM1 (Kad- cyla ® , Roche). In this review of the literature, we present the mechanisms of action, the pre-clinical data, the clinical data, the safety and the ongoing studies regarding these two therapies." @default.
- W3048097962 created "2020-08-13" @default.
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- W3048097962 date "2015-01-01" @default.
- W3048097962 modified "2023-10-13" @default.
- W3048097962 title "Pertuzumab et T-DM1 : de nouvelles perspectives dans le traitement du cancer du sein HER2 positif Pertuzumab and T-DM1: New Perspectives in the Treatment of HER2-positive Breast Cancer" @default.
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