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- W3048105480 endingPage "1008" @default.
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- W3048105480 abstract "Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causing coronavirus disease 2019 (COVID‐19) is the biggest pandemic of our lifetime to date. No effective treatment is yet in sight for this catastrophic illness. Several antiviral agents and vaccines are in clinical trials, and drug repurposings as immediate and alternative choices are also under consideration. Immunomodulatory agents like hydroxychloroquine (HCQ) as well as biological disease‐modifying anti‐rheumatic drugs (bDMARDs) such as tocilizumab and anakinra received worldwide attention for treatment of critical patients with COVID‐19. This is of interest to rheumatologists, who are well versed with rational use of these agents. This brief review addresses the understandings of some of the common immunopathogenetic mechanisms in the context of autoimmune rheumatic diseases like systemic lupus erythematosus (SLE) and COVID‐19. Apart from demographic comparisons, the role of type I interferons (IFN), presence of antiphospholipid antibodies and finally mechanism of action of HCQ in both the scenarios are discussed here. High risks for fatal disease in COVID‐19 include older age, metabolic syndrome, male gender, and individuals who develop delayed type I IFN response. HCQ acts by different mechanisms including prevention of cellular entry of SARS‐CoV‐2 and inhibition of type I IFN signaling. Recent controversies regarding efficacy of HCQ in management of COVID‐19 warrant more studies in that direction. Autoantibodies were also reported in severe acute respiratory syndrome (SARS) as well as in COVID‐19. Rheumatologists need to wait and see whether SARS‐CoV‐2 infection triggers development of autoimmunity in patients with COVID‐19 infection in the long run." @default.
- W3048105480 created "2020-08-13" @default.
- W3048105480 creator A5066425245 @default.
- W3048105480 creator A5071371708 @default.
- W3048105480 date "2020-08-01" @default.
- W3048105480 modified "2023-09-26" @default.
- W3048105480 title "Understanding immunopathological fallout of human coronavirus infections including COVID‐19: Will they cross the path of rheumatologists?" @default.
- W3048105480 cites W1594574415 @default.
- W3048105480 cites W1662940398 @default.
- W3048105480 cites W1668771408 @default.
- W3048105480 cites W1972126235 @default.
- W3048105480 cites W1977728069 @default.
- W3048105480 cites W1984064716 @default.
- W3048105480 cites W1989215732 @default.
- W3048105480 cites W1996743514 @default.
- W3048105480 cites W2003131595 @default.
- W3048105480 cites W2003210438 @default.
- W3048105480 cites W2013682359 @default.
- W3048105480 cites W2025080738 @default.
- W3048105480 cites W2026108760 @default.
- W3048105480 cites W2034273529 @default.
- W3048105480 cites W2036477696 @default.
- W3048105480 cites W2043044678 @default.
- W3048105480 cites W2049537492 @default.
- W3048105480 cites W2095807050 @default.
- W3048105480 cites W2117336218 @default.
- W3048105480 cites W2158118659 @default.
- W3048105480 cites W2164533762 @default.
- W3048105480 cites W2267315119 @default.
- W3048105480 cites W2292472819 @default.
- W3048105480 cites W2417092592 @default.
- W3048105480 cites W2461654689 @default.
- W3048105480 cites W2476198543 @default.
- W3048105480 cites W2507341513 @default.
- W3048105480 cites W2514582747 @default.
- W3048105480 cites W2518536270 @default.
- W3048105480 cites W2521741120 @default.
- W3048105480 cites W2521810353 @default.
- W3048105480 cites W253635173 @default.
- W3048105480 cites W2542088537 @default.
- W3048105480 cites W2584791255 @default.
- W3048105480 cites W2809821375 @default.
- W3048105480 cites W2965379348 @default.
- W3048105480 cites W2999629617 @default.
- W3048105480 cites W3004709581 @default.
- W3048105480 cites W3004940273 @default.
- W3048105480 cites W3009885589 @default.
- W3048105480 cites W3009912996 @default.
- W3048105480 cites W3011134208 @default.
- W3048105480 cites W3011178559 @default.
- W3048105480 cites W3011201358 @default.
- W3048105480 cites W3011224398 @default.
- W3048105480 cites W3013768434 @default.
- W3048105480 cites W3013899502 @default.
- W3048105480 cites W3013959692 @default.
- W3048105480 cites W3014003872 @default.
- W3048105480 cites W3014206579 @default.
- W3048105480 cites W3014573995 @default.
- W3048105480 cites W3014663601 @default.
- W3048105480 cites W3015607499 @default.
- W3048105480 cites W3016010853 @default.
- W3048105480 cites W3016200057 @default.
- W3048105480 cites W3016288338 @default.
- W3048105480 cites W3017125154 @default.
- W3048105480 cites W3017233408 @default.
- W3048105480 cites W3018221920 @default.
- W3048105480 cites W3018868982 @default.
- W3048105480 cites W3019773443 @default.
- W3048105480 cites W3020301027 @default.
- W3048105480 cites W3020578654 @default.
- W3048105480 cites W3021575042 @default.
- W3048105480 cites W3022366615 @default.
- W3048105480 cites W3022407124 @default.
- W3048105480 cites W3022807497 @default.
- W3048105480 cites W3023172625 @default.
- W3048105480 cites W3023346879 @default.
- W3048105480 cites W3023452186 @default.
- W3048105480 cites W3024521558 @default.
- W3048105480 cites W3025918884 @default.
- W3048105480 cites W3025972894 @default.
- W3048105480 cites W3026232146 @default.
- W3048105480 cites W3026824481 @default.
- W3048105480 cites W3028835529 @default.
- W3048105480 cites W3029266363 @default.
- W3048105480 cites W3034016318 @default.
- W3048105480 cites W3034537415 @default.
- W3048105480 doi "https://doi.org/10.1111/1756-185x.13909" @default.
- W3048105480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7436450" @default.
- W3048105480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32779341" @default.
- W3048105480 hasPublicationYear "2020" @default.
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