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- W3048108283 abstract "BackgroundA cytokine storm conceivably contributes to manifestations of corona virus disease (COVID-19). Inflammatory cytokines such as interleukin-6 (IL-6) cause acute liver injury while serum detectability indicates systemic inflammation.AimsWe explored a link between systemic IL-6, related acute phase proteins and liver injury in hospitalized COVID-19 patients.Methods655 patients with suspected COVID-19 were screened in the emergency department at the University Hospital of Innsbruck, Austria, between February and April 2020. 96 patients (∼15%) were hospitalized with COVID-19. 15 patients required intensive-care treatment (ICT). Plasma aminotransferases, alkaline phosphatase, bilirubin, and gamma glutamyl transferase, as well as IL-6, C-reactive protein (CRP), ferritin and lactate dehydrogenase (LDH) were determined by standard clinical assays.ResultsOf all hospitalized COVID-19 patients, 41 (42%) showed elevated aspartate aminotransferase (AST) concentration. COVID-19 patients with elevated AST exhibited significantly higher IL-6 (p < 0.001), ferritin (p < 0.001), LDH (p < 0.001) and CRP (p < 0.05) serum concentrations compared to patients with normal AST. Liver injury correlated with systemic IL-6 (p < 0.001), CRP (p < 0.001), ferritin (p < 0.001) and LDH (p < 0.001) concentration. In COVID-19 patients requiring ICT, correlations were more pronounced.ConclusionSystemic inflammation could be a fuel for hepatic injury in COVID-19." @default.
- W3048108283 created "2020-08-13" @default.
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- W3048108283 date "2021-02-01" @default.
- W3048108283 modified "2023-10-17" @default.
- W3048108283 title "Systemic inflammation as fuel for acute liver injury in COVID-19" @default.
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- W3048108283 doi "https://doi.org/10.1016/j.dld.2020.08.004" @default.
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