Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048128675> ?p ?o ?g. }
- W3048128675 endingPage "284" @default.
- W3048128675 startingPage "253" @default.
- W3048128675 abstract "Spray-drying is a very well established technology, used for converting emulsions, suspensions, dispersions, or liquids into fine, dispersible particles by the use of an atomizer into a hot drying gas medium. It is a reliable and reproducible technique for particle design and tailored production, suited for a variety of applications, including drug delivery. The oral route is by far the preferred route of administration and, among other advantages, has easy-to-follow therapeutic regimens, and therefore, the highest patient compliance. Considering the myriad of advantages of advanced fabrication methods like spray-drying over conventional particle fabrication methods, the spray-drying technique holds potential in the formulation of oral drug delivery systems with improved solubility and, thereby, oral bioavailability. In this chapter, we review the principles of spray-drying, the equipment configurations used, the parameters and variables affecting particle formulation, and the main considerations for a successful industrial scale-up. We also discuss the formulation of drugs/drug delivery systems for oral administration using spray-drying, providing examples of micro/nano-particles and pure drug particles that have demonstrated the potential of this technology to overcome the limited bioavailability of drug formulations produced by other fabrication methods." @default.
- W3048128675 created "2020-08-13" @default.
- W3048128675 creator A5004912857 @default.
- W3048128675 creator A5024426748 @default.
- W3048128675 creator A5071356523 @default.
- W3048128675 creator A5072925575 @default.
- W3048128675 date "2020-01-01" @default.
- W3048128675 modified "2023-09-25" @default.
- W3048128675 title "Spray-drying for the formulation of oral drug delivery systems" @default.
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