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• W3048129807 abstract "Purpose To quantitatively compare dynamic 19 F and single breath hyperpolarized 129 Xe MRI for the detection of ventilation abnormalities in subjects with mild cystic fibrosis (CF) lung disease. Methods Ten participants with stable CF and a baseline FEV1 > 70% completed a single imaging session where dynamic 19 F and single breath 129 Xe lung ventilation images were acquired on a 3T MRI scanner. Ventilation defect percentages (VDP) values between 19 F early‐breath, 19 F maximum‐ventilation, 129 Xe low‐resolution, and 129 Xe high‐resolution images were compared. Dynamic 19 F images were used to determine gas wash‐in/out rates in regions of ventilation congruency and mismatch between 129 Xe and 19 F. Results VDP values from high‐resolution 129 Xe images were greater than from low‐resolution images ( P = .001), although these values were significantly correlated (r = 0.68, P = .03). Early‐breath 19 F VDP and max‐vent 19 F VDP also showed significant correlation (r = 0.75, P = .012), with early‐breath 19 F VDP values being significantly greater ( P < .001). No correlation in VDP values were detected between either 19 F method or high‐res 129 Xe images. In addition, the location and volume of ventilation defects were often different when comparing 129 Xe and 19 F images from the same subject. Areas of ventilation congruence displayed the expected ventilation kinetics, while areas of ventilation mismatch displayed abnormally slow gas wash‐in and wash‐out. Conclusion In CF subjects, ventilation abnormalities are identified by both 19 F and HP 129 Xe imaging. However, these ventilation abnormalities are not entirely congruent. 19 F and HP 129 Xe imaging provide complementary information that enable differentiation of normally ventilated, slowly ventilated, and non‐ventilated regions in the lungs." @default.
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• W3048129807 date "2020-08-08" @default.
• W3048129807 modified "2023-10-14" @default.
• W3048129807 title "Comparison of single breath hyperpolarized ¹²⁹Xe MRI with dynamic ¹⁹F MRI in cystic fibrosis lung disease" @default.
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• W3048129807 doi "https://doi.org/10.1002/mrm.28457" @default.
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