Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048133778> ?p ?o ?g. }
- W3048133778 endingPage "293" @default.
- W3048133778 startingPage "278" @default.
- W3048133778 abstract ": Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acute inflammation, chronic inflammatory processes within the central nervous system (CNS) are crucial for the development of brain pathologies including depression. The synthesis of eicosanoids is catalysed primarily by cyclooxygenases (COX), which are involved in the production of pro-inflammatory AA metabolites, including prostaglandins and thromboxanes. Moreover, eicosanoid synthesis is catalysed by lipoxygenases (LOXs), which generate both leukotrienes and anti-inflammatory derivatives such as lipoxins. Thus, AA metabolites have double- edged pro-inflammatory and anti-inflammatory, pro-resolving properties, and an imbalance between these metabolites has been proposed as a contributor or even the basis for chronic neuroinflammatory effects. This review focuses on important evidence regarding eicosanoid-related pathways (with special emphasis on prostaglandins and lipoxins) that has added a new layer of complexity to the idea of targeting the double-edged AA-derivative pathways for therapeutic benefits in depression. We also sought to explore future research directions that can support a pro-resolving response to control the balance between eicosanoids and thus to reduce the chronic neuroinflammation that underlies at least a portion of depressive disorders." @default.
- W3048133778 created "2020-08-13" @default.
- W3048133778 creator A5004187120 @default.
- W3048133778 creator A5004924903 @default.
- W3048133778 creator A5027163504 @default.
- W3048133778 creator A5079453042 @default.
- W3048133778 creator A5085933249 @default.
- W3048133778 date "2020-12-31" @default.
- W3048133778 modified "2023-10-18" @default.
- W3048133778 title "The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression." @default.
- W3048133778 cites W1482299255 @default.
- W3048133778 cites W1597473130 @default.
- W3048133778 cites W1806538103 @default.
- W3048133778 cites W1818367061 @default.
- W3048133778 cites W1856034726 @default.
- W3048133778 cites W1883938883 @default.
- W3048133778 cites W1964147273 @default.
- W3048133778 cites W1964635429 @default.
- W3048133778 cites W1964927867 @default.
- W3048133778 cites W1967606901 @default.
- W3048133778 cites W1968248096 @default.
- W3048133778 cites W1971273396 @default.
- W3048133778 cites W1976362095 @default.
- W3048133778 cites W1976582031 @default.
- W3048133778 cites W1976770818 @default.
- W3048133778 cites W1980496798 @default.
- W3048133778 cites W1980661511 @default.
- W3048133778 cites W1983760936 @default.
- W3048133778 cites W1984103995 @default.
- W3048133778 cites W1985299782 @default.
- W3048133778 cites W1985438873 @default.
- W3048133778 cites W1990014836 @default.
- W3048133778 cites W1992332088 @default.
- W3048133778 cites W1994616470 @default.
- W3048133778 cites W1995222167 @default.
- W3048133778 cites W1996059296 @default.
- W3048133778 cites W1996267589 @default.
- W3048133778 cites W2003556082 @default.
- W3048133778 cites W2005479057 @default.
- W3048133778 cites W2006221512 @default.
- W3048133778 cites W2007187686 @default.
- W3048133778 cites W2015725986 @default.
- W3048133778 cites W2017003937 @default.
- W3048133778 cites W2018269249 @default.
- W3048133778 cites W2018809236 @default.
- W3048133778 cites W2019506702 @default.
- W3048133778 cites W2022120020 @default.
- W3048133778 cites W2030691041 @default.
- W3048133778 cites W2031084334 @default.
- W3048133778 cites W2033084955 @default.
- W3048133778 cites W2034873089 @default.
- W3048133778 cites W2038753304 @default.
- W3048133778 cites W2044473166 @default.
- W3048133778 cites W2049808835 @default.
- W3048133778 cites W2052094743 @default.
- W3048133778 cites W2053479959 @default.
- W3048133778 cites W2054109306 @default.
- W3048133778 cites W2054415514 @default.
- W3048133778 cites W2060345189 @default.
- W3048133778 cites W2061212294 @default.
- W3048133778 cites W2061293248 @default.
- W3048133778 cites W2061809825 @default.
- W3048133778 cites W2065862894 @default.
- W3048133778 cites W2072886318 @default.
- W3048133778 cites W2073059894 @default.
- W3048133778 cites W2075545649 @default.
- W3048133778 cites W2075624234 @default.
- W3048133778 cites W2077129216 @default.
- W3048133778 cites W2078124330 @default.
- W3048133778 cites W2078927723 @default.
- W3048133778 cites W2079394877 @default.
- W3048133778 cites W2079604770 @default.
- W3048133778 cites W2081449811 @default.
- W3048133778 cites W2082739219 @default.
- W3048133778 cites W2084363696 @default.
- W3048133778 cites W2084380835 @default.
- W3048133778 cites W2087657929 @default.
- W3048133778 cites W2089417699 @default.
- W3048133778 cites W2090335670 @default.
- W3048133778 cites W2093839463 @default.
- W3048133778 cites W2095272329 @default.
- W3048133778 cites W2096856875 @default.
- W3048133778 cites W2097740790 @default.
- W3048133778 cites W2099283003 @default.
- W3048133778 cites W2107507992 @default.
- W3048133778 cites W2113203684 @default.
- W3048133778 cites W2115430420 @default.
- W3048133778 cites W2117395711 @default.
- W3048133778 cites W2123869725 @default.
- W3048133778 cites W2124922239 @default.
- W3048133778 cites W2129935236 @default.
- W3048133778 cites W2133285177 @default.
- W3048133778 cites W2141412547 @default.
- W3048133778 cites W2148374854 @default.
- W3048133778 cites W2156150528 @default.
- W3048133778 cites W2171223017 @default.
- W3048133778 cites W2229954584 @default.
- W3048133778 cites W2245266827 @default.