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- W3048134291 abstract "Abstract We report herein a nonbiomimetic strategy for the total synthesis of the plicamine‐type alkaloids zephycarinatines C and D. The key feature of the synthesis is a stereoselective reductive radical ipso ‐cyclization using visible‐light‐mediated photoredox catalysis. This cyclization enabled the construction of a 6,6‐spirocyclic core structure through the addition of a carbon‐centered radical onto the aromatic ring. Biological evaluation of zephycarinatines and their derivatives revealed that the synthetic derivative with a keto group displays moderate inhibitory activity against LPS‐induced NO production. This approach could offer future opportunities to expand the chemical diversity of plicamine‐type alkaloids as well as providing useful intermediates for their syntheses." @default.
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- W3048134291 date "2020-09-11" @default.
- W3048134291 modified "2023-10-17" @default.
- W3048134291 title "Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical <i>ipso</i> ‐Cyclization" @default.
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- W3048134291 doi "https://doi.org/10.1002/anie.202009399" @default.
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