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- W3048141424 abstract "ABSTRACT The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC). We assembled richly sampled vancomycin pharmacokinetic data from three studies comprising 47 adults with various levels of renal function. With Pmetrics, the nonparametric population modeling package for R, we compared AUCs estimated from models derived from trough-only and peak-trough depleted versions of the full data set and characterized the relationship between the vancomycin trough concentration and AUC. The trough-only and peak-trough depleted data sets underestimated the true AUCs compared to the full model by a mean (95% confidence interval) of 23% (11 to 33%; P = 0.0001) and 14% (7 to 19%; P" @default.
- W3048141424 created "2020-08-13" @default.
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- W3048141424 date "2020-08-07" @default.
- W3048141424 modified "2023-09-23" @default.
- W3048141424 title "Fluorosis causing spinal cord compression" @default.
- W3048141424 cites W2917362747 @default.
- W3048141424 doi "https://doi.org/10.1136/practneurol-2020-002618" @default.
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