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- W3048146548 endingPage "511" @default.
- W3048146548 startingPage "502" @default.
- W3048146548 abstract "Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a vital modulator of low-densitylipoprotein cholesterol (LDL-C) , is raised in hepatocytes and released into plasma where it bindsto LDL receptors (LDLR), leading to their cleavage. PCSK9 adheres to the epidermal growthfactor-like repeat A (EGF-A) domain of the LDLR which is confirmed by crystallography. LDLRexpression is adjusted at the transcriptional level through sterol regulatory element bindingprotein 2 (SREBP-2) and at the post translational stages, specifically through PCSK9, and theinducible degrader of the LDLR PCSK9 inhibition is an appealing new method for reducing theconcentration of LDL-C. In this review the role of PCSK9 in lipid homeostasis was elucidated, theeffect of PCSK9 on atherosclerosis was highlighted, and contemporary therapeutic techniquesthat focused on PCSK9 were summarized. Several restoration methods to inhibit PCSK9 havebeen proposed which concentrate on both extracellular and intracellular PCSK9, and theyinclude blockage of PCSK9 production by using gene silencing agents and blockage of it’sbinding to LDLR through antibodies and inhibition of PCSK9 autocatalytic processes by tinymolecule inhibitors." @default.
- W3048146548 created "2020-08-13" @default.
- W3048146548 creator A5018885033 @default.
- W3048146548 creator A5029008361 @default.
- W3048146548 creator A5029466725 @default.
- W3048146548 creator A5047547796 @default.
- W3048146548 creator A5050819763 @default.
- W3048146548 creator A5058046926 @default.
- W3048146548 creator A5063720599 @default.
- W3048146548 date "2020-08-09" @default.
- W3048146548 modified "2023-10-07" @default.
- W3048146548 title "PCSK9: A Key Target for the Treatment of Cardiovascular Disease (CVD)" @default.
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