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- W3048148308 abstract "The ketogenic diet (KD), a high-lipid and low-carbohydrate diet, has been used in the treatment of epilepsy, neurodegenerative disorders, inborn errors of metabolism and cancer; however, the exact mechanism/s of its therapeutic effect is not completely known. We hypothesized that sirtuins (SIRT)—a group of seven NAD-dependent enzymes and important regulators of energy metabolism may be altered under KD treatment. HT22 hippocampal murine neurons were incubated with two important KD metabolites–beta-hydroxybutyrate (BHB) (the predominant ketone body) and decanoic acid (C10), both accumulating under KD. Enzyme activity, protein, and gene expressions of SIRT 1-4, enzyme capacities of the mitochondrial respiratory chain complexes (MRC), citrate synthase (CS) and gene expression of monocarboxylate transporters were measured in control (untreated) and KD-treated cells. Incubation with both–BHB and C10 resulted in significant elevation of SIRT1 enzyme activity and an overall upregulation of the MRC. C10 incubation showed prominent increases in maximal activities of complexes I + III and complex IV of the MRC and ratios of their activities to that of CS, pointing towards a more efficient functioning of the mitochondria in C10-treated cells." @default.
- W3048148308 created "2020-08-13" @default.
- W3048148308 creator A5021686155 @default.
- W3048148308 creator A5077459164 @default.
- W3048148308 date "2020-08-08" @default.
- W3048148308 modified "2023-10-09" @default.
- W3048148308 title "Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine Neurons" @default.
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- W3048148308 doi "https://doi.org/10.3390/nu12082379" @default.
- W3048148308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7468807" @default.
- W3048148308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32784510" @default.
- W3048148308 hasPublicationYear "2020" @default.
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