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- W3048152775 abstract "ABSTRACT Objective: To conduct a systematic review and meta-analysis describing the association of thyroid function with posttraumatic stress disorder (PTSD) in adults. Methods: The authors conducted a comprehensive search from databases’ inception to July 20, 2018. The meta-analysis included studies that reported mean values and standard deviation (SD) of thyroid hormone levels (thyroid-stimulating hormone lTSH], free thyroxine lFT4], free triiodothyronine lFT3], total T4 lTT4], and total T3 lTT3]) in patients with PTSD compared with controls. Five reviewers worked independently, in duplicate, to determine study inclusion, extract data, and assess risk of bias. The mean value and SD of the thyroid function tests were used to calculate the mean difference for each variable. Random-effects models for meta-analyses were applied. Results: The meta-analysis included 10 observational studies at low-to-moderate risk of bias. Studies included 674 adults (373 PTSD, 301 controls). The meta-analytic estimates showed higher levels of FT3 (+0.28 pg/mL; P = .001) and TT3 (+18.90 ng/dL; P = .005) in patients with PTSD compared to controls. There were no differences in TSH, FT4, or TT4 levels between groups. In the subgroup analysis, patients with combat-related PTSD still had higher FT3 (+0.36 pg/mL; P = .0004) and higher TT3 (+31.62 ng/dL; P Conclusion: There is scarce evidence regarding the association of thyroid disorders with PTSD. These findings add to the growing literature suggesting that thyroid function changes may be associated with PTSD." @default.
- W3048152775 created "2020-08-13" @default.
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- W3048152775 date "2020-10-01" @default.
- W3048152775 modified "2023-09-23" @default.
- W3048152775 title "Association of Thyroid Function with Posttraumatic Stress Disorder: a Systematic Review and Meta-Analysis" @default.
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- W3048152775 doi "https://doi.org/10.4158/ep-2020-0104" @default.
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