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• W3048155624 endingPage "109130" @default.
• W3048155624 startingPage "109130" @default.
• W3048155624 abstract "Abstract Objective To characterize quantitatively a single-photon emission computed tomography/computed tomography (SPECT/CT) system through experiments carried out on three-dimensional (3D) printed phantoms with bioinspired anatomic geometries. Materials and methods The sensitivity factor of the SPECT/CT system was obtained after correcting the image quality degrading effects. Photon attenuation correction was carried out through CT attenuation maps. Scattering was corrected by 2 methods. The first method introduces a compensation factor based on photopeak and scatter window widths, which corrects the 3D image during iterative reconstruction algorithm. The second estimates scatter within a photopeak window, which is applied projection by projection before the 3D reconstruction. Partial volume effect was corrected using a calibration method based on spheres of different sizes. A liver-like and a multisphere phantom were designed and 3D printed. SPECT/CT images of the designed phantoms filled with different activities were acquired and quantified. A correlation coefficient based on linear regression was calculated with the aim of comparing proposed methods. Results The quantitative SPECT methodology allowed quantification with percentage errors between 1.01-8.96%. The activity measurements validated the 99mTc quantitative performance of the SPECT/CT system. The statistical analysis showed correlation coefficients of 1.00 for the first method and 0.99 for the second one. Conclusion The implementation of two alternative methodologies for the calculation of sensitivity factors, allowed to correct image quality degrading effects, satisfying all the suggested stages in imaging quantification. The designed phantoms allowed to assess the characterization of a SPECT/CT system. This study demonstrates the effectiveness of 3D printing to develop bioinspired phantoms for the quantitative assessment of 99mTc imaging." @default.
• W3048155624 created "2020-08-13" @default.
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• W3048155624 date "2020-12-01" @default.
• W3048155624 modified "2023-09-23" @default.
• W3048155624 title "Tomographic 99mTc radioactivity quantification in three-dimensional printed polymeric phantoms with bioinspired geometries" @default.
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• W3048155624 doi "https://doi.org/10.1016/j.radphyschem.2020.109130" @default.
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