FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048162181> ?p ?o ?g. }

• W3048162181 endingPage "88" @default.
• W3048162181 startingPage "78" @default.
• W3048162181 abstract "Objective The pathophysiologic events that precede the onset of rheumatoid arthritis (RA) remain incompletely understood. This study was undertaken to identify changes in the serum proteome that precede the onset of RA, with the aim of providing new insights into the pathogenic mechanisms that lead to its development. Methods In a cohort of first-degree relatives of Indigenous North American RA patients, the SomaScan proteomics platform was used to determine the levels of 1,307 proteins in multiple longitudinal serum samples from 17 individuals who were followed up prospectively to the time of disease onset. Proteomic signatures from this group of individuals (designated the progressor group) were compared to those in a group of individuals who were considered at risk of developing RA, stratified as either positive (n = 63) or negative (n = 47) for anti–citrullinated protein antibodies (ACPAs) (designated the at-risk group). Machine learning was used to identify a protein signature that could accurately classify those individuals at highest risk of future RA development. Results A preclinical proteomic signature that differentiated RA progressors from at-risk individuals, irrespective of ACPA status, was identified (area under the curve 0.913, accuracy 91.2%). Importantly, the predictive preclinical proteomic signature was present not only in serum samples obtained close to the onset of RA, but also in serum samples obtained a median of 30.9 months prior to onset. Network analysis implicated the activation of Toll-like receptor 2 and production of tumor necrosis factor and interleukin-1 as key events that precede RA progression. Conclusion Alterations in the serum proteome in the preclinical phase of RA can emerge years prior to the onset of disease. Our findings suggest that the serum proteome provides a rich source of proteins serving both to classify at-risk individuals and to identify molecular pathways involved in the development of clinically detectable RA." @default.
• W3048162181 created "2020-08-13" @default.
• W3048162181 creator A5023196886 @default.
• W3048162181 creator A5040372628 @default.
• W3048162181 creator A5047961314 @default.
• W3048162181 creator A5060472497 @default.
• W3048162181 creator A5071084607 @default.
• W3048162181 creator A5072931739 @default.
• W3048162181 creator A5083180220 @default.
• W3048162181 creator A5090942754 @default.
• W3048162181 date "2020-11-10" @default.
• W3048162181 modified "2023-10-11" @default.
• W3048162181 title "Association of a Serum Protein Signature With Rheumatoid Arthritis Development" @default.
• W3048162181 cites W1968183450 @default.
• W3048162181 cites W2016382347 @default.
• W3048162181 cites W2017560560 @default.
• W3048162181 cites W2029799473 @default.
• W3048162181 cites W2046321585 @default.
• W3048162181 cites W2054049887 @default.
• W3048162181 cites W2056326147 @default.
• W3048162181 cites W2062526524 @default.
• W3048162181 cites W2062637839 @default.
• W3048162181 cites W2068576802 @default.
• W3048162181 cites W2080696131 @default.
• W3048162181 cites W2084373725 @default.
• W3048162181 cites W2085192554 @default.
• W3048162181 cites W2089929962 @default.
• W3048162181 cites W2104635612 @default.
• W3048162181 cites W2110177517 @default.
• W3048162181 cites W2123142652 @default.
• W3048162181 cites W2128619333 @default.
• W3048162181 cites W2128952811 @default.
• W3048162181 cites W2197257524 @default.
• W3048162181 cites W2332635847 @default.
• W3048162181 cites W2566283148 @default.
• W3048162181 cites W2607154592 @default.
• W3048162181 cites W2743735384 @default.
• W3048162181 cites W2767195935 @default.
• W3048162181 cites W2811033401 @default.
• W3048162181 cites W2885636345 @default.
• W3048162181 cites W2886363262 @default.
• W3048162181 cites W2889654109 @default.
• W3048162181 cites W2921430480 @default.
• W3048162181 cites W2944312460 @default.
• W3048162181 cites W2945412194 @default.
• W3048162181 cites W2970725246 @default.
• W3048162181 cites W2994160326 @default.
• W3048162181 cites W2998322151 @default.
• W3048162181 cites W4211111012 @default.
• W3048162181 doi "https://doi.org/10.1002/art.41483" @default.
• W3048162181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32770634" @default.
• W3048162181 hasPublicationYear "2020" @default.
• W3048162181 type Work @default.
• W3048162181 sameAs 3048162181 @default.
• W3048162181 citedByCount "13" @default.
• W3048162181 countsByYear W30481621812020 @default.
• W3048162181 countsByYear W30481621812021 @default.
• W3048162181 countsByYear W30481621812022 @default.
• W3048162181 countsByYear W30481621812023 @default.
• W3048162181 crossrefType "journal-article" @default.
• W3048162181 hasAuthorship W3048162181A5023196886 @default.
• W3048162181 hasAuthorship W3048162181A5040372628 @default.
• W3048162181 hasAuthorship W3048162181A5047961314 @default.
• W3048162181 hasAuthorship W3048162181A5060472497 @default.
• W3048162181 hasAuthorship W3048162181A5071084607 @default.
• W3048162181 hasAuthorship W3048162181A5072931739 @default.
• W3048162181 hasAuthorship W3048162181A5083180220 @default.
• W3048162181 hasAuthorship W3048162181A5090942754 @default.
• W3048162181 hasConcept C104317684 @default.
• W3048162181 hasConcept C104397665 @default.
• W3048162181 hasConcept C126322002 @default.
• W3048162181 hasConcept C143998085 @default.
• W3048162181 hasConcept C203014093 @default.
• W3048162181 hasConcept C2776232647 @default.
• W3048162181 hasConcept C2777575956 @default.
• W3048162181 hasConcept C2779134260 @default.
• W3048162181 hasConcept C2781197716 @default.
• W3048162181 hasConcept C46111723 @default.
• W3048162181 hasConcept C55493867 @default.
• W3048162181 hasConcept C60644358 @default.
• W3048162181 hasConcept C71924100 @default.
• W3048162181 hasConcept C72563966 @default.
• W3048162181 hasConcept C86803240 @default.
• W3048162181 hasConceptScore W3048162181C104317684 @default.
• W3048162181 hasConceptScore W3048162181C104397665 @default.
• W3048162181 hasConceptScore W3048162181C126322002 @default.
• W3048162181 hasConceptScore W3048162181C143998085 @default.
• W3048162181 hasConceptScore W3048162181C203014093 @default.
• W3048162181 hasConceptScore W3048162181C2776232647 @default.
• W3048162181 hasConceptScore W3048162181C2777575956 @default.
• W3048162181 hasConceptScore W3048162181C2779134260 @default.
• W3048162181 hasConceptScore W3048162181C2781197716 @default.
• W3048162181 hasConceptScore W3048162181C46111723 @default.
• W3048162181 hasConceptScore W3048162181C55493867 @default.
• W3048162181 hasConceptScore W3048162181C60644358 @default.
• W3048162181 hasConceptScore W3048162181C71924100 @default.
• W3048162181 hasConceptScore W3048162181C72563966 @default.
• W3048162181 hasConceptScore W3048162181C86803240 @default.

• next