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• W3048162452 abstract "Abstract Many cells and tissues exhibit chirality that stems from the chirality of proteins and polymers. In the C. elegans zygote actomyosin contractility drives chiral rotation of the entire cortex circumferentially around the division plane during anaphase. How contractility is translated to cell-scale chirality, and what dictates handedness, are unknown. Septins are candidate contributors to cell-scale chirality because they anchor and crosslink the actomyosin cytoskeleton. We report that septins are required for anaphase cortical rotation. In contrast, the formin CYK-1, which we found to be enriched in the posterior in early anaphase, is not required for cortical rotation, but contributes to its chirality. Simultaneous loss of septin and CYK-1 function led to abnormal and often reversed cortical rotation. Our results suggest that anaphase contractility leads to chiral rotation by releasing torsional stress generated during formin-based polymerization, which is polarized along the cell anterior-posterior axis, and which accumulates due to actomyosin network connectivity. Our findings shed light on the molecular and physical bases for cellular chirality in the C. elegans zygote. We also identify conditions in which chiral rotation fails but animals are developmentally viable, opening avenues for future work on the relationship between early embryonic cellular chirality and animal body plan." @default.
• W3048162452 created "2020-08-13" @default.
• W3048162452 creator A5000268919 @default.
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• W3048162452 date "2020-08-07" @default.
• W3048162452 modified "2023-10-15" @default.
• W3048162452 title "Septins and a formin have distinct functions in anaphase chiral cortical rotation in the C. elegans zygote" @default.
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• W3048162452 doi "https://doi.org/10.1101/2020.08.07.242123" @default.
• W3048162452 hasPublicationYear "2020" @default.
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