FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048165009> ?p ?o ?g. }

• W3048165009 abstract "Abstract Background Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behavioral indicators of Alzheimer’s disease (AD), especially when they require the binding of multiple features (e.g., color and shape). Recently, it has become possible to directly measure amyloid and tau levels in vivo via positron emission tomography (PET). To this point, these behavioral and neurochemical markers have not been compared in humans with AD or at risk for it. Methods In a cross-sectional study, we compared VSTM performance to tau and amyloid concentrations, measured by PET, in individuals certain to develop AD by virtue of their inheritance of the presenilin-1 E280A mutation. These included 21 clinically unimpaired subjects and 7 subjects with early mild cognitive impairment (MCI), as well as 30 family members who were not carriers of the mutation. Results We found that VSTM performance correlated strongly with tau in entorhinal cortex and inferior temporal lobe, and also with amyloid when examining asymptomatic carriers only. The condition requiring binding was not preferentially linked to tau—in fact, the non-binding “shape only” condition showed a stronger relationship. Conclusions The results confirm VSTM’s status as an early marker of AD pathology and raise interesting questions as to the course of binding-specific versus non-binding aspects of VSTM in early AD." @default.
• W3048165009 created "2020-08-13" @default.
• W3048165009 creator A5001340799 @default.
• W3048165009 creator A5001795846 @default.
• W3048165009 creator A5005435770 @default.
• W3048165009 creator A5006568776 @default.
• W3048165009 creator A5021217850 @default.
• W3048165009 creator A5021945125 @default.
• W3048165009 creator A5024744959 @default.
• W3048165009 creator A5038245254 @default.
• W3048165009 creator A5043161963 @default.
• W3048165009 creator A5047768726 @default.
• W3048165009 creator A5055843167 @default.
• W3048165009 creator A5075852366 @default.
• W3048165009 creator A5076768887 @default.
• W3048165009 creator A5077383411 @default.
• W3048165009 creator A5088247542 @default.
• W3048165009 creator A5090842068 @default.
• W3048165009 date "2020-08-21" @default.
• W3048165009 modified "2023-10-16" @default.
• W3048165009 title "Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer’s disease" @default.
• W3048165009 cites W1747565446 @default.
• W3048165009 cites W1829710617 @default.
• W3048165009 cites W1973526765 @default.
• W3048165009 cites W1974594322 @default.
• W3048165009 cites W1986951455 @default.
• W3048165009 cites W1987926645 @default.
• W3048165009 cites W1991979438 @default.
• W3048165009 cites W2003724861 @default.
• W3048165009 cites W2019528205 @default.
• W3048165009 cites W2044605802 @default.
• W3048165009 cites W2051489981 @default.
• W3048165009 cites W2052157612 @default.
• W3048165009 cites W2052742260 @default.
• W3048165009 cites W2060164680 @default.
• W3048165009 cites W2068805221 @default.
• W3048165009 cites W2069909557 @default.
• W3048165009 cites W2073271453 @default.
• W3048165009 cites W2096695700 @default.
• W3048165009 cites W2098580427 @default.
• W3048165009 cites W2099550030 @default.
• W3048165009 cites W2121091792 @default.
• W3048165009 cites W2125754969 @default.
• W3048165009 cites W2129497119 @default.
• W3048165009 cites W2140928605 @default.
• W3048165009 cites W2142904655 @default.
• W3048165009 cites W2152541739 @default.
• W3048165009 cites W2159150910 @default.
• W3048165009 cites W2215958284 @default.
• W3048165009 cites W2225619291 @default.
• W3048165009 cites W2267715130 @default.
• W3048165009 cites W2309442902 @default.
• W3048165009 cites W2595643095 @default.
• W3048165009 cites W2605747520 @default.
• W3048165009 cites W2751501952 @default.
• W3048165009 cites W2763301808 @default.
• W3048165009 cites W2793496929 @default.
• W3048165009 cites W2794050431 @default.
• W3048165009 cites W2883805651 @default.
• W3048165009 cites W2934663403 @default.
• W3048165009 cites W328819816 @default.
• W3048165009 cites W4233488446 @default.
• W3048165009 doi "https://doi.org/10.1186/s13195-020-00660-z" @default.
• W3048165009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7442980" @default.
• W3048165009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32825838" @default.
• W3048165009 hasPublicationYear "2020" @default.
• W3048165009 type Work @default.
• W3048165009 sameAs 3048165009 @default.
• W3048165009 citedByCount "18" @default.
• W3048165009 countsByYear W30481650092021 @default.
• W3048165009 countsByYear W30481650092022 @default.
• W3048165009 countsByYear W30481650092023 @default.
• W3048165009 crossrefType "journal-article" @default.
• W3048165009 hasAuthorship W3048165009A5001340799 @default.
• W3048165009 hasAuthorship W3048165009A5001795846 @default.
• W3048165009 hasAuthorship W3048165009A5005435770 @default.
• W3048165009 hasAuthorship W3048165009A5006568776 @default.
• W3048165009 hasAuthorship W3048165009A5021217850 @default.
• W3048165009 hasAuthorship W3048165009A5021945125 @default.
• W3048165009 hasAuthorship W3048165009A5024744959 @default.
• W3048165009 hasAuthorship W3048165009A5038245254 @default.
• W3048165009 hasAuthorship W3048165009A5043161963 @default.
• W3048165009 hasAuthorship W3048165009A5047768726 @default.
• W3048165009 hasAuthorship W3048165009A5055843167 @default.
• W3048165009 hasAuthorship W3048165009A5075852366 @default.
• W3048165009 hasAuthorship W3048165009A5076768887 @default.
• W3048165009 hasAuthorship W3048165009A5077383411 @default.
• W3048165009 hasAuthorship W3048165009A5088247542 @default.
• W3048165009 hasAuthorship W3048165009A5090842068 @default.
• W3048165009 hasBestOaLocation W30481650091 @default.
• W3048165009 hasConcept C142724271 @default.
• W3048165009 hasConcept C15744967 @default.
• W3048165009 hasConcept C169760540 @default.
• W3048165009 hasConcept C175344181 @default.
• W3048165009 hasConcept C2776485563 @default.
• W3048165009 hasConcept C2777633098 @default.
• W3048165009 hasConcept C2778186239 @default.
• W3048165009 hasConcept C2779134260 @default.
• W3048165009 hasConcept C2780715579 @default.
• W3048165009 hasConcept C2781099131 @default.

• next