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• W3048167488 endingPage "176" @default.
• W3048167488 startingPage "143" @default.
• W3048167488 abstract "Oral delivery of a drug poses many formulation challenges due to the highly varying physiological environment of the gastrointestinal tract (GIT). Nanosized drug carriers are promising platforms for oral delivery of hard-to-deliver and emerging therapeutic payloads (e.g., lipophilic drugs, macromolecules, among others). This is showcased by the plethora of studies on oral payload delivery using nano drug delivery systems (nDDS). Nanoparticulate carriers, through their unique properties are effective in addressing the challenges posed by the GIT. However, the size, shape, chemical composition, and the surface charge of the nanoparticles are the key considerations that define the interactions between nanoparticles and the GIT interface, and thus the delivery capabilities of the nanoparticles. Our increased understanding of these interactions, enabled by improved in vitro and in vivo testing platforms, is greatly helpful in designing of the next generation of nDDS to improve payload bioavailability, enhance permeation across the GIT, and enable controlled release of drug payloads for a more localized therapy. In this chapter, we summarize the current progress in nanoparticle carrier systems and the effect of their morphology and surface characteristics on their ability to deliver therapeutics via the oral route." @default.
• W3048167488 created "2020-08-13" @default.
• W3048167488 creator A5031413304 @default.
• W3048167488 creator A5055486123 @default.
• W3048167488 creator A5065350638 @default.
• W3048167488 date "2020-01-01" @default.
• W3048167488 modified "2023-09-26" @default.
• W3048167488 title "Size, shape and surface charge considerations of orally delivered nanomedicines" @default.
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