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- W3048174914 endingPage "5663" @default.
- W3048174914 startingPage "5663" @default.
- W3048174914 abstract "Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disorder limited to the lung. New findings, starting from our proteomics studies on IPF, suggest that systemic involvement with altered molecular mechanisms and metabolic disorder is an underlying cause of fibrosis. The role of metabolic dysregulation in the pathogenesis of IPF has not been extensively studied, despite a recent surge of interest. In particular, our studies on bronchoalveolar lavage fluid have shown that the renin–angiotensin–aldosterone system (RAAS), the hypoxia/oxidative stress response, and changes in iron and lipid metabolism are involved in onset of IPF. These processes appear to interact in an intricate manner and to be related to different fibrosing pathologies not directly linked to the lung environment. The disordered metabolism of carbohydrates, lipids, proteins and hormones has been documented in lung, liver, and kidney fibrosis. Correcting these metabolic alterations may offer a new strategy for treating fibrosis. This paper focuses on the role of metabolic dysregulation in the pathogenesis of IPF and is a continuation of our previous studies, investigating metabolic dysregulation as a new target for fibrosis therapy." @default.
- W3048174914 created "2020-08-13" @default.
- W3048174914 creator A5001098559 @default.
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- W3048174914 creator A5082781749 @default.
- W3048174914 date "2020-08-07" @default.
- W3048174914 modified "2023-09-27" @default.
- W3048174914 title "Metabolic Dysregulation in Idiopathic Pulmonary Fibrosis" @default.
- W3048174914 cites W1420728361 @default.
- W3048174914 cites W1564861448 @default.
- W3048174914 cites W1616573322 @default.
- W3048174914 cites W1804140162 @default.
- W3048174914 cites W1846284774 @default.
- W3048174914 cites W1968937909 @default.
- W3048174914 cites W1975618241 @default.
- W3048174914 cites W1978302160 @default.
- W3048174914 cites W1993559550 @default.
- W3048174914 cites W1997074732 @default.
- W3048174914 cites W2000877933 @default.
- W3048174914 cites W2018767973 @default.
- W3048174914 cites W2030611470 @default.
- W3048174914 cites W2033727182 @default.
- W3048174914 cites W2047401978 @default.
- W3048174914 cites W2053727964 @default.
- W3048174914 cites W2056229206 @default.
- W3048174914 cites W2066681223 @default.
- W3048174914 cites W2073882423 @default.
- W3048174914 cites W2076738925 @default.
- W3048174914 cites W2079528855 @default.
- W3048174914 cites W2088288953 @default.
- W3048174914 cites W2095947329 @default.
- W3048174914 cites W2102017305 @default.
- W3048174914 cites W2103994597 @default.
- W3048174914 cites W2116241430 @default.
- W3048174914 cites W2117098575 @default.
- W3048174914 cites W2121971740 @default.
- W3048174914 cites W2133481218 @default.
- W3048174914 cites W2153102033 @default.
- W3048174914 cites W2166628970 @default.
- W3048174914 cites W2258703222 @default.
- W3048174914 cites W2335968657 @default.
- W3048174914 cites W2336891991 @default.
- W3048174914 cites W2396164396 @default.
- W3048174914 cites W2504372097 @default.
- W3048174914 cites W2510472879 @default.
- W3048174914 cites W2511161488 @default.
- W3048174914 cites W2562020714 @default.
- W3048174914 cites W2563054448 @default.
- W3048174914 cites W2583803798 @default.
- W3048174914 cites W2590827547 @default.
- W3048174914 cites W2612248505 @default.
- W3048174914 cites W2740317277 @default.
- W3048174914 cites W2741267358 @default.
- W3048174914 cites W2759943049 @default.
- W3048174914 cites W2766390746 @default.
- W3048174914 cites W2766645546 @default.
- W3048174914 cites W2768516807 @default.
- W3048174914 cites W2769783328 @default.
- W3048174914 cites W2774394294 @default.
- W3048174914 cites W2792516799 @default.
- W3048174914 cites W2793516758 @default.
- W3048174914 cites W2797947316 @default.
- W3048174914 cites W2798081375 @default.
- W3048174914 cites W2823705647 @default.
- W3048174914 cites W2884114811 @default.
- W3048174914 cites W2889197569 @default.
- W3048174914 cites W2893137183 @default.
- W3048174914 cites W2901740709 @default.
- W3048174914 cites W2904917569 @default.
- W3048174914 cites W2940403538 @default.
- W3048174914 cites W2941056732 @default.
- W3048174914 cites W2946328073 @default.
- W3048174914 cites W2951991612 @default.
- W3048174914 cites W2953324049 @default.
- W3048174914 cites W2955212273 @default.
- W3048174914 cites W2957039367 @default.
- W3048174914 cites W2965877420 @default.
- W3048174914 cites W2969531212 @default.
- W3048174914 cites W2971352226 @default.
- W3048174914 cites W2972032745 @default.
- W3048174914 cites W2974204766 @default.
- W3048174914 cites W2981000288 @default.
- W3048174914 cites W2981051693 @default.
- W3048174914 cites W2981069029 @default.
- W3048174914 cites W2985181908 @default.
- W3048174914 cites W2985200574 @default.
- W3048174914 cites W2990138847 @default.
- W3048174914 cites W2992565351 @default.
- W3048174914 cites W2996643561 @default.
- W3048174914 cites W2996707518 @default.
- W3048174914 cites W3000798572 @default.
- W3048174914 cites W3000956463 @default.
- W3048174914 cites W3006553906 @default.