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• W3048176450 endingPage "1061" @default.
• W3048176450 startingPage "1051" @default.
• W3048176450 abstract "A novel adjuvant evaluation system for safety and immunogenicity is needed. Vaccination is important for infection prevention, for example, from influenza viruses. Adjuvants are considered critical for improving the effectiveness of influenza vaccines. Adjuvant development is an important issue in influenza vaccine design.A conventional in vivo evaluation method for vaccine safety has been limited in analyzing phenotypic and pathological changes. Therefore, it is difficult to obtain information on the changes at the molecular level. This review aims to explain the recently developed genomics analysis-based vaccine adjuvant safety evaluation tools verified by AddaVaxTM and polyinosinic-polycytidylic acid (poly I:C) using 18 biomarker genes and whole-virion inactivated influenza vaccine as a toxicity control. Genomics analyzes would help provide safety and efficacy information regarding influenza vaccine design by facilitating appropriate adjuvant selection.The efficacy and safety profiles of influenza vaccines and adjuvants using genomics technologies provide useful information regarding immunogenicity, which is related to safety and efficacy. This approach provides important information to select appropriate inoculation routes, combinations of vaccine antigens and adjuvants, and dosing amounts. The efficacy of vaccine adjuvant evaluation by genomics analysis should be verified by various studies using various vaccines in the future." @default.
• W3048176450 created "2020-08-13" @default.
• W3048176450 creator A5040425668 @default.
• W3048176450 creator A5058573964 @default.
• W3048176450 creator A5067391422 @default.
• W3048176450 date "2020-08-24" @default.
• W3048176450 modified "2023-10-17" @default.
• W3048176450 title "Pharmacodynamic and safety considerations for influenza vaccine and adjuvant design" @default.
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