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- W3048178875 startingPage "2220" @default.
- W3048178875 abstract "Background: One of the most frequently used medications for treating gastrointestinal disorders is proton pump inhibitor (PPI), which reportedly has potential adverse effects. Although the relationship between the use of PPIs and the risk of pancreatic cancer has been extensively investigated, the results remain inconsistent. Hence, this meta-analysis aimed to evaluate such relationship. Methods: We searched for literature and subsequently included 10 studies (seven case–control and three cohort studies; 948,782 individuals). The pooled odds ratio (OR) and 95% confidence intervals (CI) for pancreatic cancer were estimated using a random-effects model. We also conducted sensitivity analysis and subgroup analysis. Results: The pooled OR of the meta-analysis was 1.698 (95% CI: 1.200–2.402, p = 0.003), with a substantial heterogeneity (I2 = 98.75%, p < 0.001). Even when studies were excluded one by one, the pooled OR remained statistically significant. According to the stratified subgroup analyses, PPI use, and pancreatic cancer incidence were positively associated, regardless of the study design, quality of study, country, and PPI type. Conclusion: PPI use may be associated with the increased risk of pancreatic cancer. Hence, caution is needed when using PPIs among patients with a high risk of pancreatic cancer." @default.
- W3048178875 created "2020-08-13" @default.
- W3048178875 creator A5023749947 @default.
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- W3048178875 date "2020-08-08" @default.
- W3048178875 modified "2023-10-15" @default.
- W3048178875 title "Does the Use of Proton Pump Inhibitors Increase the Risk of Pancreatic Cancer? A Systematic Review and Meta-Analysis of Epidemiologic Studies" @default.
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- W3048178875 doi "https://doi.org/10.3390/cancers12082220" @default.
- W3048178875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7463819" @default.
- W3048178875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32784492" @default.
- W3048178875 hasPublicationYear "2020" @default.
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