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• W3048187299 startingPage "e001053" @default.
• W3048187299 abstract "Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is a distinct clinical entity with a much better prognosis after (chemo)radiotherapy than HPV-negative OPSCC, especially in patients with a concomitant intratumoral HPV-specific and type-1 cytokine-oriented T cell response. However, knowledge on the type of myeloid cells and their coordination with intratumoral T cells and influence on patient outcome in OPSCC is lacking. Methods We analyzed the presence of intratumoral myeloid cells and their relationship to tumor-infiltrating T cells and patient outcome in a well-described cohort of HPV16 + patients with OPSCC using multispectral immunofluorescence, flow cytometry and functional analyses. Results We show that the tumor microenvironment of HPV16 + OPSCC tumors with such an ongoing HPV16-specific T cell response is highly infiltrated with a newly defined CD163 + cytokine-producing subset of conventional dendritic cell type 2 (cDC2), called DC3. These CD163 + cDC2 predominantly stimulated type 1 T cell polarization and produced high levels of interleukin-12 (IL-12) and IL-18, required for IFNγ and IL-22 production by T cells after cognate antigen stimulation. Tumor-infiltration with these CD163 + cDC2 positively correlated with the infiltration by Tbet + and tumor-specific T cells, and with prolonged survival. Conclusions These data suggest an important role for intratumoral CD163 + cDC2 in stimulating tumor-infiltrating T cells to exert their antitumor effects." @default.
• W3048187299 created "2020-08-13" @default.
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• W3048187299 date "2020-08-01" @default.
• W3048187299 modified "2023-10-17" @default.
• W3048187299 title "CD163⁺ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer" @default.
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• W3048187299 doi "https://doi.org/10.1136/jitc-2020-001053" @default.
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