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• W3048191323 endingPage "2097" @default.
• W3048191323 startingPage "2085" @default.
• W3048191323 abstract "The care given to moderate and severe traumatic brain injury (TBI) patients may be hampered by the inability to tailor their treatments according to their neurological status. Contrast-enhanced near-infrared spectroscopy (NIRS) with indocyanine green (ICG) could be a suitable neuromonitoring tool.Monitoring the effective attenuation coefficients (EAC), we compared the ICG kinetics between five TBI and five extracranial trauma patients, following a venous-injection of 5 mL of 1 mg/mL ICG, using two commercially available NIRS devices.A significantly slower passage of the dye through the brain of the TBI group was observed in two parameters related to the first ICG inflow into the brain (P=0.04; P=0.01). This is likely related to the reduction of cerebral perfusion following TBI. Significant changes in ICG optical properties minutes after injection (P=0.04) were registered. The acquisition of valid optical data in a clinical environment was challenging.Future research should analyze abnormalities in the ICG kinetic following brain trauma, test how these values can enhance care in TBI, and adapt the current optical devices to clinical settings. Also, studies on the pattern in changes of ICG optical properties after venous injection can improve the accuracy of the values detected." @default.
• W3048191323 created "2020-08-13" @default.
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• W3048191323 date "2020-11-01" @default.
• W3048191323 modified "2023-10-17" @default.
• W3048191323 title "Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study" @default.
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• W3048191323 doi "https://doi.org/10.21037/qims-20-742" @default.
• W3048191323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7547258" @default.
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