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- W3048199514 endingPage "1126" @default.
- W3048199514 startingPage "1107" @default.
- W3048199514 abstract "Abstract RAS proteins control a number of essential cellular processes as molecular switches in the human body. Presumably due to their important signalling role, RAS proteins are among the most frequently mutated oncogenes in human cancers. Hence, numerous efforts were done to develop appropriate therapies for RAS-mutant cancers in the last three decades. This review aimed to collect all of the reported small molecules that affect RAS signalling. These molecules can be divided in four main branches. First, we address approaches blocking RAS membrane association. Second, we focus on the stabilization efforts of non-productive RAS complexes. Third, we examine the approach to block RAS downstream signalling through disturbance of RAS-effector complex formation. Finally, we discuss direct inhibition; particularly the most recently reported covalent inhibitors, which are already advanced to human clinical trials." @default.
- W3048199514 created "2020-08-13" @default.
- W3048199514 creator A5022888378 @default.
- W3048199514 creator A5063702078 @default.
- W3048199514 date "2020-08-07" @default.
- W3048199514 modified "2023-10-18" @default.
- W3048199514 title "Small molecule inhibitors of RAS proteins with oncogenic mutations" @default.
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