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- W3048201237 endingPage "4077" @default.
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- W3048201237 abstract "Abstract Pictet‐Spengler reaction is a typical condensation reaction of β‐arylethylamine or Tryptamine with an aldehyde or ketone followed by ring closure to generate tetrahydroisoquinoline (THIQ) and Tetrahydro‐β‐carboline (THβC), respectively. Both these key skeletons represent huge range of structurally diverse naturally occurring isoquinoline and indole alkaloids. Nature has synthesized structurally complex Reserpine, Ajmalicine as well as other related alkaloids using various biosynthetic pathways via Pictet‐Spengler reaction followed by post‐Pictet‐Spengler cyclization (PPSC) stratergy. This biosynthetic process is the short and reliable method to access diverse range of polycyclic heterocycles. Over the period of last sixty years, several researchers have synthesized complex alkaloids without highlighting the synthetic utility of the post‐Pictet‐Spengler cyclization strategy. We summarized the synthesis of numerous natural products and related natural product inspired heterocyclic scaffolds which follow the PPSC strategy to demonstrate its usefulness for the construction of diverse compound collection. magnified image" @default.
- W3048201237 created "2020-08-13" @default.
- W3048201237 creator A5068247384 @default.
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- W3048201237 creator A5069515028 @default.
- W3048201237 creator A5070124390 @default.
- W3048201237 creator A5082751654 @default.
- W3048201237 date "2020-08-31" @default.
- W3048201237 modified "2023-10-11" @default.
- W3048201237 title "Post‐Pictet‐Spengler Cyclization (PPSC): A Strategy to Synthesize Polycyclic β‐Carboline‐Derived Natural Products and Biologically Active N‐Heterocycles" @default.
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