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• W3048201616 abstract "Breast cancer patients over the age of 65 are more likely to suffer chemotherapy side effects, with premature discontinuation, which negatively affects survival.We conducted a retrospective cohort study enrolling breast cancer patients; dose reductions or interruptions of chemotherapy have been collected, as well as side effects. Progression-free survival was determined by Kaplan-Meier and evaluated for its association with reduction/suspension. The study included 128 women (median age: 71).Nineteen patients experienced cardiotoxicity, while dosage of chemotherapy was reduced in 23 patients (18.0%), and 14 (10.9%) had premature interruptions. Dose reduction/interruptions were associated with numerically worse progression-free survival (78.2 vs 94.8 months; p = 0.10).Reduction/discontinuation of chemotherapy due to side effects affected nearly 30% of our population, potentially worsening outcomes." @default.
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• W3048201616 date "2020-08-10" @default.
• W3048201616 modified "2023-10-03" @default.
• W3048201616 title "Side effects of adjuvant chemotherapy and their impact on outcome in elderly breast cancer patients: a cohort study" @default.
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• W3048201616 doi "https://doi.org/10.2144/fsoa-2020-0076" @default.
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