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- W3048204456 abstract "Despite the efficacy of adjuvant chemotherapy in colorectal cancer (CRC), almost half of all patients who undergo surgical resection with curative intent will expe- rience relapse. It remains a necessity to find an adjuvant the- rapy that is more effective. Regular use of aspirin reduces the risk of CRC and adenoma's development. This anti- neoplastic effect is partially due to inhibition of PIK3/AKT pathway through COX-2 inhibition. Two recent retrospec- tive studies suggested that regular use of aspirin after CRC diagnosis improves survival and decreases the risk of recur- rence in patients with PIK3CA-mutated tumour, but it was not confirmed in a recent study. Aspirin could be active as a targeted therapy. However, the adverse events, particularly in older patients, could limit its use in routine clinical prac- tice. A prospective randomized evaluation is required after the resection of CRC with PIK3CA mutation." @default.
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- W3048204456 date "2014-01-01" @default.
- W3048204456 modified "2023-10-17" @default.
- W3048204456 title "Traitement adjuvant du cancer colorectal : l'aspirine, une biothérapie ciblée ? Adjuvant Therapy in Colorectal Cancer: Aspirin, a Targeted Therapy?" @default.
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