FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048206208> ?p ?o ?g. }

• W3048206208 endingPage "2681" @default.
• W3048206208 startingPage "2650" @default.
• W3048206208 abstract "Abstract Parkinson's disease (PD) is one of the most common neurodegenerative disorders that manifest various motor and nonmotor symptoms. Although currently available therapies can alleviate some of the symptoms, the disease continues to progress, leading eventually to severe motor and cognitive decline and reduced life expectancy. The past two decades have witnessed rapid progress in our understanding of the molecular and genetic pathogenesis of the disease, paving the way for the development of new therapeutic approaches to arrest or delay the neurodegenerative process. As a result of these advances, biomarker‐driven subtyping is making it possible to stratify PD patients into more homogeneous subgroups that may better respond to potential genetic‐molecular pathway targeted disease‐modifying therapies. Therapeutic nucleic acid oligomers can bind to target gene sequences with very high specificity in a base‐pairing manner and precisely modulate downstream molecular events. Recently, nucleic acid therapeutics have proven effective in the treatment of a number of severe neurological and neuromuscular disorders, drawing increasing attention to the possibility of developing novel molecular therapies for PD. In this review, we update the molecular pathogenesis of PD and discuss progress in the use of antisense oligonucleotides, small interfering RNAs, short hairpin RNAs, aptamers, and microRNA‐based therapeutics to target critical elements in the pathogenesis of PD that could have the potential to modify disease progression. In addition, recent advances in the delivery of nucleic acid compounds across the blood–brain barrier and challenges facing PD clinical trials are also reviewed." @default.
• W3048206208 created "2020-08-13" @default.
• W3048206208 creator A5001672241 @default.
• W3048206208 creator A5008704373 @default.
• W3048206208 creator A5043341509 @default.
• W3048206208 creator A5080459494 @default.
• W3048206208 date "2020-08-06" @default.
• W3048206208 modified "2023-10-16" @default.
• W3048206208 title "Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era" @default.
• W3048206208 cites W135934099 @default.
• W3048206208 cites W144423133 @default.
• W3048206208 cites W1501727007 @default.
• W3048206208 cites W1502920935 @default.
• W3048206208 cites W1530028553 @default.
• W3048206208 cites W1544196343 @default.
• W3048206208 cites W1561072761 @default.
• W3048206208 cites W1582304017 @default.
• W3048206208 cites W1588992473 @default.
• W3048206208 cites W1721689174 @default.
• W3048206208 cites W1759837577 @default.
• W3048206208 cites W1857105967 @default.
• W3048206208 cites W1896246110 @default.
• W3048206208 cites W1902964798 @default.
• W3048206208 cites W1918258073 @default.
• W3048206208 cites W1949934773 @default.
• W3048206208 cites W1965295915 @default.
• W3048206208 cites W1965641455 @default.
• W3048206208 cites W1966800232 @default.
• W3048206208 cites W1967573239 @default.
• W3048206208 cites W1969800514 @default.
• W3048206208 cites W1970611232 @default.
• W3048206208 cites W1972989638 @default.
• W3048206208 cites W1974924674 @default.
• W3048206208 cites W1983315832 @default.
• W3048206208 cites W1986820918 @default.
• W3048206208 cites W1990881110 @default.
• W3048206208 cites W1992887404 @default.
• W3048206208 cites W199354732 @default.
• W3048206208 cites W1993576291 @default.
• W3048206208 cites W1994164143 @default.
• W3048206208 cites W1994357966 @default.
• W3048206208 cites W1995121204 @default.
• W3048206208 cites W1997188614 @default.
• W3048206208 cites W2001314633 @default.
• W3048206208 cites W2003172650 @default.
• W3048206208 cites W2003181166 @default.
• W3048206208 cites W2008704732 @default.
• W3048206208 cites W2014850107 @default.
• W3048206208 cites W2015263736 @default.
• W3048206208 cites W2021439462 @default.
• W3048206208 cites W2025722577 @default.
• W3048206208 cites W2026717532 @default.
• W3048206208 cites W2030120319 @default.
• W3048206208 cites W2033425827 @default.
• W3048206208 cites W2036838479 @default.
• W3048206208 cites W2037695327 @default.
• W3048206208 cites W2042968293 @default.
• W3048206208 cites W2043082218 @default.
• W3048206208 cites W2044851147 @default.
• W3048206208 cites W2048388887 @default.
• W3048206208 cites W2056363797 @default.
• W3048206208 cites W2057298198 @default.
• W3048206208 cites W2057758054 @default.
• W3048206208 cites W2059111801 @default.
• W3048206208 cites W2062119268 @default.
• W3048206208 cites W2064036940 @default.
• W3048206208 cites W2064350685 @default.
• W3048206208 cites W2065439630 @default.
• W3048206208 cites W2068785219 @default.
• W3048206208 cites W2075832622 @default.
• W3048206208 cites W2076431356 @default.
• W3048206208 cites W2076863390 @default.
• W3048206208 cites W2077881833 @default.
• W3048206208 cites W2080718344 @default.
• W3048206208 cites W2082175825 @default.
• W3048206208 cites W2083111107 @default.
• W3048206208 cites W2090183104 @default.
• W3048206208 cites W2092293921 @default.
• W3048206208 cites W2100333422 @default.
• W3048206208 cites W2103986409 @default.
• W3048206208 cites W2114382100 @default.
• W3048206208 cites W2115295034 @default.
• W3048206208 cites W2115670524 @default.
• W3048206208 cites W2115943716 @default.
• W3048206208 cites W2118601234 @default.
• W3048206208 cites W2119212619 @default.
• W3048206208 cites W2120820989 @default.
• W3048206208 cites W2123342333 @default.
• W3048206208 cites W2123431154 @default.
• W3048206208 cites W2126549314 @default.
• W3048206208 cites W2128520557 @default.
• W3048206208 cites W2128768698 @default.
• W3048206208 cites W2129676131 @default.
• W3048206208 cites W2129743050 @default.
• W3048206208 cites W2133712961 @default.
• W3048206208 cites W2136549268 @default.
• W3048206208 cites W2142545021 @default.
• W3048206208 cites W2143313350 @default.

• next