Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048209087> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3048209087 endingPage "996" @default.
- W3048209087 startingPage "992" @default.
- W3048209087 abstract "Abstract Cancer medicine is a challenging field with an increasing range of promising therapies and combinations. Increasingly, personalised medicine shows promise to improve cancer outcomes – response, symptom control, survival and cure. However, optimal dosing is an under‐appreciated aspect of personalised anticancer therapy, with few clinical trials addressing this specific issue. This position paper aims to inform various health professionals about the principles that guide anticancer drug dose selection and modifications. We discuss the available evidence base for personalised dosing, as well as the professional judgement required by experienced oncology physicians to determine the most appropriate dose for each patient. We provide nine steps to guide clinicians and trainees in this process, based on: pharmacology of each agent (absorption, distribution, metabolism, elimination and mechanism of action); scientific evidence for recommended doses; professional knowledge of patients' unique phenotype (adiposity, comorbidities, etc.); previous drug tolerance; individual dose adjustment in combination therapy; communication and documentation, with the added need for ongoing monitoring and adjustment. We strongly propose professional education and future research towards optimal dosing." @default.
- W3048209087 created "2020-08-13" @default.
- W3048209087 creator A5002098356 @default.
- W3048209087 creator A5008701409 @default.
- W3048209087 creator A5008919576 @default.
- W3048209087 creator A5041526616 @default.
- W3048209087 creator A5046335734 @default.
- W3048209087 creator A5046503557 @default.
- W3048209087 creator A5063111253 @default.
- W3048209087 creator A5068720728 @default.
- W3048209087 date "2020-08-01" @default.
- W3048209087 modified "2023-09-26" @default.
- W3048209087 title "Science and art of anticancer drug dosing: nine steps to personalised therapy" @default.
- W3048209087 cites W1524595223 @default.
- W3048209087 cites W1892571469 @default.
- W3048209087 cites W1910716144 @default.
- W3048209087 cites W2024447346 @default.
- W3048209087 cites W2043021219 @default.
- W3048209087 cites W2051905300 @default.
- W3048209087 cites W2063899456 @default.
- W3048209087 cites W2096195999 @default.
- W3048209087 cites W2110681616 @default.
- W3048209087 cites W2123526148 @default.
- W3048209087 cites W2135656951 @default.
- W3048209087 cites W2138926750 @default.
- W3048209087 cites W2139057757 @default.
- W3048209087 cites W2139664150 @default.
- W3048209087 cites W2147869809 @default.
- W3048209087 cites W2149246244 @default.
- W3048209087 cites W2158975681 @default.
- W3048209087 cites W2161988278 @default.
- W3048209087 cites W2162661389 @default.
- W3048209087 cites W2748586176 @default.
- W3048209087 cites W2765920053 @default.
- W3048209087 cites W4237114858 @default.
- W3048209087 cites W4247289520 @default.
- W3048209087 doi "https://doi.org/10.1111/imj.14948" @default.
- W3048209087 hasPublicationYear "2020" @default.
- W3048209087 type Work @default.
- W3048209087 sameAs 3048209087 @default.
- W3048209087 citedByCount "0" @default.
- W3048209087 crossrefType "journal-article" @default.
- W3048209087 hasAuthorship W3048209087A5002098356 @default.
- W3048209087 hasAuthorship W3048209087A5008701409 @default.
- W3048209087 hasAuthorship W3048209087A5008919576 @default.
- W3048209087 hasAuthorship W3048209087A5041526616 @default.
- W3048209087 hasAuthorship W3048209087A5046335734 @default.
- W3048209087 hasAuthorship W3048209087A5046503557 @default.
- W3048209087 hasAuthorship W3048209087A5063111253 @default.
- W3048209087 hasAuthorship W3048209087A5068720728 @default.
- W3048209087 hasBestOaLocation W30482090872 @default.
- W3048209087 hasConcept C160735492 @default.
- W3048209087 hasConcept C162324750 @default.
- W3048209087 hasConcept C177713679 @default.
- W3048209087 hasConcept C199360897 @default.
- W3048209087 hasConcept C2777288759 @default.
- W3048209087 hasConcept C2780035454 @default.
- W3048209087 hasConcept C3019806175 @default.
- W3048209087 hasConcept C41008148 @default.
- W3048209087 hasConcept C50522688 @default.
- W3048209087 hasConcept C56666940 @default.
- W3048209087 hasConcept C71924100 @default.
- W3048209087 hasConcept C98274493 @default.
- W3048209087 hasConceptScore W3048209087C160735492 @default.
- W3048209087 hasConceptScore W3048209087C162324750 @default.
- W3048209087 hasConceptScore W3048209087C177713679 @default.
- W3048209087 hasConceptScore W3048209087C199360897 @default.
- W3048209087 hasConceptScore W3048209087C2777288759 @default.
- W3048209087 hasConceptScore W3048209087C2780035454 @default.
- W3048209087 hasConceptScore W3048209087C3019806175 @default.
- W3048209087 hasConceptScore W3048209087C41008148 @default.
- W3048209087 hasConceptScore W3048209087C50522688 @default.
- W3048209087 hasConceptScore W3048209087C56666940 @default.
- W3048209087 hasConceptScore W3048209087C71924100 @default.
- W3048209087 hasConceptScore W3048209087C98274493 @default.
- W3048209087 hasIssue "8" @default.
- W3048209087 hasLocation W30482090871 @default.
- W3048209087 hasLocation W30482090872 @default.
- W3048209087 hasOpenAccess W3048209087 @default.
- W3048209087 hasPrimaryLocation W30482090871 @default.
- W3048209087 hasRelatedWork W1517854031 @default.
- W3048209087 hasRelatedWork W1581935460 @default.
- W3048209087 hasRelatedWork W1988967387 @default.
- W3048209087 hasRelatedWork W2006788578 @default.
- W3048209087 hasRelatedWork W2136148117 @default.
- W3048209087 hasRelatedWork W2576731998 @default.
- W3048209087 hasRelatedWork W2754407282 @default.
- W3048209087 hasRelatedWork W2947337648 @default.
- W3048209087 hasRelatedWork W2964339291 @default.
- W3048209087 hasRelatedWork W4328048994 @default.
- W3048209087 hasVolume "50" @default.
- W3048209087 isParatext "false" @default.
- W3048209087 isRetracted "false" @default.
- W3048209087 magId "3048209087" @default.
- W3048209087 workType "article" @default.