FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048211026> ?p ?o ?g. }

• W3048211026 abstract "Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence on the development of T1D, are still missing. Drugs, such as betamethasone, are used during this critical period without exploring possible effects later in life. Betamethasone can interact with the development and function of the two main players in T1D, the immune system and the pancreatic β-cells. Short-term or persistent changes in any of these two players may influence the initiation of the autoimmune reaction against β-cells. In this review, we focus on the ability of betamethasone to induce alterations in the immune system, impairing the recognition of autoantigens. At the same time, betamethasone affects β-cell gene expression and apoptosis rate, reducing the danger signals that will attract unwanted attention from the immune system. These effects may synergise to hinder the autoimmune attack. In this review, we compile scattered evidence to provide a better understanding of the basic relationship between betamethasone and T1D, laying the foundation for future studies on human cohorts that will help to fully grasp the role of betamethasone in the development of T1D." @default.
• W3048211026 created "2020-08-13" @default.
• W3048211026 creator A5007893238 @default.
• W3048211026 creator A5008950634 @default.
• W3048211026 creator A5011669279 @default.
• W3048211026 creator A5016556462 @default.
• W3048211026 creator A5065602142 @default.
• W3048211026 date "2020-08-11" @default.
• W3048211026 modified "2023-10-10" @default.
• W3048211026 title "Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes" @default.
• W3048211026 cites W1525042081 @default.
• W3048211026 cites W1768066141 @default.
• W3048211026 cites W1902039366 @default.
• W3048211026 cites W1910262301 @default.
• W3048211026 cites W1931625951 @default.
• W3048211026 cites W1970446325 @default.
• W3048211026 cites W1984959662 @default.
• W3048211026 cites W1985531593 @default.
• W3048211026 cites W1991409306 @default.
• W3048211026 cites W1992642422 @default.
• W3048211026 cites W1998136841 @default.
• W3048211026 cites W2002255461 @default.
• W3048211026 cites W2011806980 @default.
• W3048211026 cites W2015357735 @default.
• W3048211026 cites W2033332949 @default.
• W3048211026 cites W2034630624 @default.
• W3048211026 cites W2036443557 @default.
• W3048211026 cites W2037618070 @default.
• W3048211026 cites W2038673601 @default.
• W3048211026 cites W2041013321 @default.
• W3048211026 cites W2044066087 @default.
• W3048211026 cites W2046353679 @default.
• W3048211026 cites W2048718083 @default.
• W3048211026 cites W2061820904 @default.
• W3048211026 cites W2062374822 @default.
• W3048211026 cites W2066955137 @default.
• W3048211026 cites W2069875129 @default.
• W3048211026 cites W2071180802 @default.
• W3048211026 cites W2073099166 @default.
• W3048211026 cites W2082167483 @default.
• W3048211026 cites W2082427068 @default.
• W3048211026 cites W2084521237 @default.
• W3048211026 cites W2085757625 @default.
• W3048211026 cites W2086460608 @default.
• W3048211026 cites W2088957333 @default.
• W3048211026 cites W2090990763 @default.
• W3048211026 cites W2093705034 @default.
• W3048211026 cites W2119315831 @default.
• W3048211026 cites W2132986686 @default.
• W3048211026 cites W2139358643 @default.
• W3048211026 cites W2152792280 @default.
• W3048211026 cites W2157655909 @default.
• W3048211026 cites W2162667045 @default.
• W3048211026 cites W2164186556 @default.
• W3048211026 cites W2166307427 @default.
• W3048211026 cites W2169101968 @default.
• W3048211026 cites W2169845440 @default.
• W3048211026 cites W2170279236 @default.
• W3048211026 cites W2191578544 @default.
• W3048211026 cites W2193088046 @default.
• W3048211026 cites W2275060683 @default.
• W3048211026 cites W2300664218 @default.
• W3048211026 cites W2325490713 @default.
• W3048211026 cites W2328332670 @default.
• W3048211026 cites W2425256690 @default.
• W3048211026 cites W2475068803 @default.
• W3048211026 cites W2479229036 @default.
• W3048211026 cites W2505163702 @default.
• W3048211026 cites W2522567023 @default.
• W3048211026 cites W2550526707 @default.
• W3048211026 cites W2553062251 @default.
• W3048211026 cites W2587941297 @default.
• W3048211026 cites W2606520198 @default.
• W3048211026 cites W2765203719 @default.
• W3048211026 cites W2767970846 @default.
• W3048211026 cites W2770280039 @default.
• W3048211026 cites W2773672092 @default.
• W3048211026 cites W2790090033 @default.
• W3048211026 cites W2801081903 @default.
• W3048211026 cites W2806001520 @default.
• W3048211026 cites W2807893746 @default.
• W3048211026 cites W2808375307 @default.
• W3048211026 cites W2914158826 @default.
• W3048211026 cites W2914650668 @default.
• W3048211026 cites W2920039369 @default.
• W3048211026 cites W2945712466 @default.
• W3048211026 cites W2952493394 @default.
• W3048211026 cites W2968647927 @default.
• W3048211026 cites W2989663485 @default.
• W3048211026 cites W2991836328 @default.
• W3048211026 cites W3000572576 @default.
• W3048211026 cites W3004037465 @default.
• W3048211026 cites W3009598951 @default.
• W3048211026 cites W3032585803 @default.
• W3048211026 cites W4239979837 @default.
• W3048211026 doi "https://doi.org/10.3389/fendo.2020.00540" @default.
• W3048211026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7431597" @default.
• W3048211026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32849311" @default.
• W3048211026 hasPublicationYear "2020" @default.
• W3048211026 type Work @default.

• next